開授課程

大學部

  上學期︰分子生物學、臨床鏡檢學實習、普通生物學

  下學期︰臨床鏡檢學含實驗

碩士班

  上學期︰無

  下學期︰無

MyLab實驗室研究方向

Our research goal is using RNA as a diagnostic and therapeutic target/tool in cancer. Tumor metastasis is a key step in facilitating cancer progression, which is theoretically an irreversible and lethal process. We mainly focus on investigating the mechanism of how cancer cells acquire the capacity to metastasize along with the possible therapeutic and diagnostic strategies. Cellular functions rely on fine-tuned regulation from DNA to RNA to protein (central dogma). As a carrier for genetic information, RNA has long been widely-recognized as a messenger for protein coding. For recent decades, a large number of accumulating research has identified new functions of noncoding RNAs (miRNA, lincRNA, circRNA, etc.), such as gene silencing, epigenetic, and protein modification. We devote ourselves to understanding the regulation of RNA processing and the resulting impact in cancer. Since most noncoding RNAs act as RNA-protein complexes (RNPs), we focus on studying the pathophysiological roles of RNA and RNA-binding protein in human cancer.

Research Field

RNA-binding protein

Post-translational regulation

Precision oncology

指導學生

無相關資料

指導學生之特殊榮譽

1.     指導賴輝寰博士生榮獲第28屆王民寧獎之「國內醫藥研究所博士班優秀論文獎」(2018)

2.    指導賴輝寰博士生榮獲柯林論文獎生物醫學領域博士論文獎(2019)

3.    指導曾培雅碩士生榮獲生物醫學聯合學術年會細胞及分子生物學學會永信李天德醫藥基金會壁報論文獎(2023)

4.    指導余雅筑大學生榮獲112年暑期研究優秀獎(2024)

5.    指導張艾欣大學生榮獲112年暑期研究優選獎(2024)

6.    指導余雅筑、莊芸晴大學生榮獲113年國家科學及技術委員會大專學生研究計畫獎助(2024)

7.    指導余雅筑大學生榮獲國立成功大學113年UR大專生專題研究成果海報展暨海報競賽-研究獎-生醫組第一名(傑出獎) (2024)

榮譽及獎勵

1.    國科會優秀年輕學者研究計畫獎助 (2014-2017)

2.    成功大學校級教學特優教師(2022)

3.    成功大學校級輔導優良教師(2022)

4.    國科會吳大猷先生紀念獎(2022)

5.    國科會2030跨世代年輕學者方案-優秀年輕學者研究計畫獎助(2022-2025)

6.    國科會吳大猷先生紀念獎獎助計畫(2023-2026)

Selected Publications Within Five Years (as a first/corresponding author)

1. Hui-Huang Lai, Jie-Ning Li, Ming-Yang Wang, Hsin-Yi Huang, Carlo M. Croce, Hui-Lung Sun, Yu-Jhen Lyu, Jui-Wen Kang, Ching-Feng Chiu, Mien-Chie Hung, Hiroshi I. Suzuki, Pai-Sheng Chen* (2018, Feb). HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis. Journal of Clinical Investigation, 2018 Feb 1;128(2):625-643. doi: 10.1172/JCI89212. (IF 13.3, Ranking 2.1%) *Corresponding Author (指導第一作者賴輝寰博士生獲第28屆王民寧獎之「國內醫藥研究所博士班優秀論文獎」以及柯林論文獎生物醫學領域博士論文獎)

2. Hui-Huang Lai, Pai-Sheng Chen* (2018, Aug). Dual mechanism of Dicer downregulation facilitates cancer metastasis. Molecular & Cellular Oncology, 24;5(5):e1472056. doi: 10.1080/23723556.2018.1472056. eCollection 2018. (IF 2.6, Ranking 54.3%) *Corresponding Author

3. Hui-Huang Lai, Li-Jyuan Lin, Liang-Yi Hung and Pai-Sheng Chen* (2018, Nov). Role of Dicer in regulating oxaliplatin resistance of colon cancer cells. Biochemical and Biophysical Research Communications, 506:87-93. pii: S0006-291X(18)32227-7. doi: 10.1016/j.bbrc.2018.10.071. [Epub ahead of print]. MOST 107-2320-B-006-009. (IF 2.5, Ranking 69%) *Corresponding Author

4. Hui-Huang Lai, Chih-Wei Li, Chih-Chen Hong, Hung-Yu Sun, Da-Liang Ou, Pai-Sheng Chen* (2019, Jan). TARBP2-mediated destabilization of Nanog overcomes sorafenib resistance in hepatocellular carcinoma. Molecular Oncology, 2019 Jan 18. doi: 10.1002/1878-0261.12449. [Epub ahead of print]. MOST 107-2320-B-006-068. (IF 5.0, Ranking 20.8%) *Corresponding Author

5. Ming-Yang Wang, Hsin-Yi Huang, Yao-Lung Kuo, Chiao Lo, Hung-Yu Sun, Yu-Jhen Lyu, Bo-Rong Chen, Jie-Ning Li, Pai-Sheng Chen*. (2019, Feb). TARBP2-Enhanced Resistance During Tamoxifen Treatment in Breast Cancer. Cancers, 2019, 11(2), 210; doi.org/10.3390/cancers11020210. European Patent Approved No. 3 539 541 (IF 4.5, Ranking 24.2%) *Corresponding Author

6. Pai-Sheng Chen#, Shao-Chieh Lin, Shaw-Jenq Tsai* (2020, Mar). Complexity in Regulating microRNA Biogenesis in Cancer. Experimental Biology and Medicine, 245(5):395-401. doi: 10.1177/1535370220907314. Epub 2020 Feb 19. (IF 2.8, Ranking 48.7%) #First Author

7. Pai-Sheng Chen#, Wen-Tai Chiu, Pei-Ling Hsu, Shih-Chieh Lin, I-Chen Peng, Chia-Yih Wang, Shaw-Jenq Tsai* (2020, May). Pathophysiological Implications of Hypoxia in Human Diseases. Journal of Biomedical Science, 27(1):63. doi: 10.1186/s12929-020-00658-7. (IF 9.0, Ranking 7.9%) #First Author

8. Jie-Ning Li, Hui-Lung Sun, Ming-Yang Wang, Pai-Sheng Chen* (2021, Jul). E-cadherin Interacts With Posttranslationally-Modified AGO2 to Enhance miRISC Activity. Frontiers in Cell and Developmental Biology, 9:671244. doi: 10.3389/fcell.2021.671244. eCollection 2021. (IF 4.6, Ranking 12.8%) *Corresponding Author

9. Jie-Ning Li, Ming-Yang Wang, Yi-Ting Chen, Yao-Lung Kuo, Pai-Sheng Chen* (2021, Dec). Expression of SnoRNA U50A Is Associated with Better Prognosis and Prolonged Mitosis in Breast Cancer. Cancers. 13(24):6304. doi: 10.3390/cancers13246304. European Patent Approved. (IF 4.9, Ranking 24.2%) *Corresponding Author

10. Yu-Yun Shao#, Pai-Sheng Chen#, Liang-In Lin, Bin-Shyun Lee, Andrew Ling, Ann-Lii Cheng, Chiun Hsu & Da-Liang Ou* (2022, Mar). Low miR-10b-3p associated with sorafenib resistance in hepatocellular carcinoma. British Journal of Cancer. doi: 10.1038/s41416-022-01759-w. Online ahead of print. (IF 8.1, Ranking 14.3%) #First Author

11. Jie-Ning Li, Zhu-Jun Loh, Hui-Wen Chen, I-Ying Lee, Jui-Hung Tsai*, Pai-Sheng Chen*. SnoRNA U50A mediates everolimus resistance in breast cancer through mTOR downregulation. Translational Oncology, Volume 48, 2024. (IF 4.5, Ranking 24.2%) *Corresponding Author 

12. Jie-Ning Li, Ming-Yang Wang, Yu-Jhen Lyu, Pownraj Brindangnanam, Mohane Selvaraj Coumar, Pai-Sheng Chen*. (2024, Aug). A transcription-independent role for HIF-1α in modulating microprocessor assembly. Nucleic Acids Research. Accepted. (IF 16.1, Ranking 1.9%) *Corresponding Author 

13. Pai-Sheng Chen#,* (2019, Feb). Regulation of Selective Proteolysis in Cancer. The Ubiquitin/Proteasome System. Matthew Summers, editor, IntechOpen, London, UNITED KINGDOM. ISBN 978-953-51-7766-1 (Invited book chapter) *Corresponding Author

Invited Talk

1.     A transcription-independent role for HIF-1α in modulating microprocessor assembly.第四屆台北表觀遺傳及染色質研討會暨台灣表觀遺傳學會2024年會 2018/07/18-22 (Invited speaker)

2.    全國醫檢生技教學調和研討會 2023/11/04

3.     A noncanonical HIF-1α pathway for metastasis control.第13屆海峽兩岸細胞生物學學術研討會 2018/07/18-22 (Invited speaker)

4.     Exoswitch: a rethink of HIF-1α. 成功大學醫學院教師研究討論會 2022/05/27 (Invited speaker)

Patents

   1.　Method of Evaluating Drug Resistance and Treatment Effect. European Patent #EP3539541 B1. Chen Pai-Sheng*, Li Jie-Ning, Kuo Yao-Lung, Wang Ming-Yang. 2020/12 Approved

   2.　Method of Evaluating Drug Resistance and Treatment Effect. US Patent #US 11,435,353 B2. Chen Pai-Sheng*, Li Jie-Ning, Kuo Yao-Lung, Wang Ming-Yang. 2022/09 Approved

   3.　Method and kit for the evaluation of the prognosis of breast cancer. European Patent #EP3540078. Chen Pai-Sheng*, Li Jie-Ning, Kuo Yao-Lung. 2022/10 Approved

Experience/Service

1. 國科會計畫複審委員

2. 國科會計畫初審委員

3. 國科會大專生研究計畫審查委員、

4. 國科會大專學生研究計畫創作獎審查委員

5. 國立臺灣大學高等教育深耕計畫─學術研究生涯發展研究計畫審查委員

6. 永信李天德醫藥科技獎審查委員

7. 成大醫院乳房醫學中心研究顧問

8. 經濟部工業局產業競爭力中心業界訪視服務專家

8. 成大醫學院教學優良及大學社會特優教師遴選委員

Invited SCI Journal Reviewer (Selected Journal list)

1.      Cancer Research (5)

2.      Cancer Communications (1)

3.      Oncogene (4)

4.      Drug Resistance Updates (2)

5.      Cancer Letters (2)

6.      Theranostics (6)

7.      Molecular Oncology (4)

8.      Therapeutic Advances in Medical Oncology (5)

9.      Oncogenesis (2)

10.    European Journal of Pharmacology (1)  

Editorial Board Member

　1.      BMC Cancer

　2.      Frontiers in Oncology

　3.      Frontiers in Cell and Developmental Biology