鄭怡琳 助理教授 Yi-Lin Cheng

  辦公室電話：5582

  辦公室地點：醫學院10樓 82-1021室

  實驗室電話：6250

  實驗室地點：醫學院10樓 82-1053室

  電子信箱：yilincheng@gs.ncku.edu.tw

  學術成大：鄭 怡琳

  Publons：Yi-Lin Cheng

開授課程

博士班

  上學期：免疫學

  下學期：無

MyLab實驗室研究方向

本實驗室的研究在探討宿主及病原菌之間的交互作用，主要針對自噬作用、外泌體生合成、及宿主蛋白和細菌成份或毒力因子間的交互作用進行探討。

有別過去幾十年來，大部分研究在探討革蘭氏陰性菌脂多醣在細胞外的角色，我們近來的研究專注在探討細胞內脂多醣所結合之宿主蛋白，及細胞內脂多醣誘導外泌體產生的機制及在敗血病中所扮演的角色。

The research interest of our group is centered on the host-pathogen interaction with specific reference to autophagic mechanisms, exosomes biogenesis, and interaction of host proteins with bacterial components or virulence factors.

Our recent study focus on the role of intracellular lipopolysaccharides (LPS), which can be exposed to cytosol of host cells via intracellular bacterial infection or endocytosis of outer membrane vesicles (OMVs) released from extracellular bacteria. LPS, which is enriched on outer membrane of Gram-negative bacteria, recognized as the critical factor for sepsis by inducing overwhelming cytokines. Over decades, people mostly studied its extracellular role. Until recently, caspase-4/-5/-11 was identified as the intracellular receptors of LPS. However, whether there is other cytosolic receptors or LPS-interacting proteins, as well as the roles of these interactions still need further investigation. Notably, exosomes, which can be induced by LPS, are identified as the critical mediator for sepsis. However, how LPS regulates exosome biogenesis for sepsis development is still largely unknown. Therefore, our group aims to investigate the following topics:

1. To explore the role of intracellular LPS-binding proteins

  探討細胞內脂多醣結合之蛋白及其角色

2. To investigate the role of intracellular LPS and bacterial outer membrane vesicles in exosomes production and the implications in sepsis

探討細胞內脂多醣和細菌外膜囊泡在外泌體產生中的角色及其對敗血症的影響

3. To verify the role of exosomes in the urinary tract infection (UTI) and the implications in sepsis, as well as acute kidney injury and chronic kidney disorders (AKI-to-CKD) transition (collaboration with Ming-Yuan Hong MD. Ph.D.)

探討外泌體在泌尿道感染中的角色及其對敗血症及急性腎損傷進展到慢性腎臟病過程中的影響（與成大急診部洪明原醫師合作）

指導學生

博士班：洪○瑩（基醫所）

碩士班：林○鈞（微免所）

學士班：黃○（醫學系）、林○亮（醫技系）、黃○恩（生科系）

指導學生之特殊榮譽

無

榮譽及獎勵

2018 Award Recipient of Postdoctoral Research Abroad Program, Ministry of Science and Technology (MOST)

(108年度科技部補助博士後赴國外研究千里馬計畫)