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莊詠鈞

莊詠鈞 副教授  Yung-Chun Chuang

一張含有 個人, 套裝, 穿著, 擺姿勢 的圖片自動產生的描述

 

  辦公室地點：醫技系4樓5794室

  電子信箱：s58981125@gmail.com

 

 

開授課程

大學部

  上學期︰無

  下學期︰無

碩士班

  上學期︰無

  下學期︰血清免疫實驗

MyLab實驗室研究方向

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指導學生

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指導學生之特殊榮譽

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榮譽及獎勵

1. First place (Virology poster) 20th Annual meeting of the Taiwan Society of Microbiology.

2. Best Poster Award. (Poster) 2011. International Symposium on Signal Transduction and Gene Regulation, Tainan, Taiwan.

3. Travel Award of NSC, Taiwan, 2012.

4. Outstanding Research Award. 2012. National Cheng Kung University Medical College.

5. Outstanding Young Person. 2014. Changhua County Government, Taiwan.

6. Year Award. 2014. Sysmex Medical Laboratory Paper Award

7. Excellent Research Award. (Poster) 2014. International Symposium on Signal Transduction and Gene Regulation, Tainan, Taiwan.

8. 中山醫學大學生物醫學科學學系-傑出系友

9. 中山醫學大學-傑出校友

10. 國立成功大學醫學檢驗生物技術學系-傑出系友

11. 國立成功大學醫學醫學院-傑出校友

12. 獲第18屆國家新創獎-企業新創獎(創新醫材與診斷技術)

13. 榮獲衛福部/經濟部2021藥物科技發展獎-金質獎(醫療器材類2022傑出生技產業獎－潛力標竿獎)

期刊論文

  1. Chuang YC, Lei HY, Lin YS, Liu HS, Wu HL, Yeh TM. (2011) Dengue virus-induced autoantibodies bind to plasminogen and enhance its activation. J Immunol 187: 6483-6490. (SCI)

  2. Lin YS, Yeh TM, Lin CF, Wan SW, Chuang YC, Hsu TK, Liu HS, Liu CC, Anderson, R., Lei HY. (2011) Molecular mimicry between virus and host and its implications for dengue disease pathogenesis. Exp Biol Med (Maywood) 236: 515-523. (SCI)

  3. Chuang YC, Lei HY, Liu HS, Lin YS, Fu TF, Yeh TM. (2011) Macrophage migration inhibitory factor induced by dengue virus infection increases vascular permeability Cytokine 54: 222-231. (SCI)

  4. Chuang YC, Su WH, Lei HY, Lin YS, Liu HS, Chang CP, Yeh TM. (2012) Macrophage migration inhibitory factor induces autophagy via reactive oxygen species generation PLoS ONE 7(5): e37613. (SCI)

  5. Lin SW, Chuang YC, Lin YS, Lei HY, Liu HS, Yeh TM. (2012) Dengue virus nonstructural protein NS1 binds to prothrombin/thrombin and inhibits prothrombin activation. J Infect 64: 325-334. (SCI)

  6. Chuang YC, Wang SY, Lin YS, Chen, HR, Yeh TM. (2013) Re-evaluation of the pathogenic roles of nonstructural protein NS1 and its antibodies during dengue virus infection. J Biomed Sci 20: 42-48 (SCI)

  7. Chuang YC, Lin YS, Liu HS, Wang JR, Yeh TM. (2013) Antibodies against thrombin in dengue patients contain both anti-thrombotic and pro-fibrinolytic activities. Thromb Haemostasis 110: 358-365. (SCI)

  8. Chuang YC, Lin YS, Liu CC, Liu HS, Liao SH, Shi MD, Lei HY, Yeh TM. (2013) Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection. J Formosa Med Assoc 112: 12-17. (SCI)

  9. Chuang YC, Lin YS, Liu HS, Yeh TM. (2014) Molecular mimicry between dengue virus and coagulation factors induces antibodies to inhibit thrombin activity and enhance fibrinolysis. J. Virol, 88: 13759-13768. (SCI)

  10. Chuang YC, Chen HR, Yeh TM. (2015) Pathogenic Roles of Macrophage Migration Inhibitory Factor during Dengue Virus Infection. Mediat Inflamm. Mediators of inflammation, 2015: 547094. (SCI)

  11. Chen HR, Chuang YC, Chao CH, Yeh TM. (2015) Macrophage migration inhibitory factor induces vascular leakage via autophagy. Biology Open, 4: 244-252. (SCI)

  12. Lai YC, Chuang YC, Chang CP, Yeh TM. (2015) Macrophage migration inhibitory factor has a permissive role in concanavalin A-induced cell death of human hepatoma cells through autophagy. Cell Death Dis. 2015 Dec 3;6:e2008.

  13. Chuang YC, Lin J, Lin YS, Wang S, Yeh TM. (2016) Dengue Virus Nonstructural Protein 1-Induced Antibodies Cross-React with Human Plasminogen and Enhance Its Activation. J Immunol. 2016, 196 (3) 1218-1226

  14. HR Chen, YC Chuang, YS Lin, HS Liu, CC Liu, GC Perng, TM Yeh. (2016) Dengue virus nonstructural protein 1 induces vascular leakage through macrophage migration inhibitory factor and autophagy PLoS neglected tropical diseases 10 (7), e0004828

  15. YC Lai, YC Chuang, CC Liu, TS Ho, YS Lin, R Anderson, TM Yeh. (2017) Antibodies Against Modified NS1 Wing Domain Peptide Protect Against Dengue Virus Infection. Scientific Reports 7 (1), 6975

  16. CH Chao, HR Chen, YC Chuang, TM Yeh. (2017) Macrophage Migration Inhibitory Factor-Induced Autophagy Contributes to Thrombin-Triggered Endothelial Hyperpermeability in Sepsis. Shock. 2017 Aug 25. doi: 10.1097/SHK.0000000000000976.

  17. Wan SW, Chen PW, Chen CY, Lai YC, Chu YT, Hung CY, Lee H, Wu HF, Chuang YC, Lin J, Chang CP, Wang S, Liu CC, Ho TS, Lin CF, Lee CK, Wu-Hsieh BA, Anderson R, Yeh TM, Lin YS. Therapeutic Effects of Monoclonal Antibody against Dengue Virus NS1 in a STAT1 Knockout Mouse Model of Dengue Infection. J Immunol. 2017 Oct 15;199(8):2834-2844. doi: 10.4049/jimmunol.1601523.

  18. Chao CH, Chen HR, Chuang YC, Yeh TM. Macrophage migration inhibitory factor-induced autophagy contributes to thrombin-triggered endothelial hyperpermeability in sepsis. Shock. 2017 Aug 25. doi: 10.1097/SHK.0000000000000976.

  19. Lai YC, Chuang YC, Liu CC, Ho TS, Lin YS, Anderson R, Yeh TM. Antibodies against modified NS1 wing domain peptide protect against dengue virus infection. Scientific Reports 7, Article number: 6975(2017)

  20. Lai YC, Chuang YC, Chane CP, Lin YS, Perng GC, Wu HC, Hsieh SL, Yeh TM. Minocycline suppresses dengue virus replication by down-regulation of macrophage migration inhibitory factor-induced autophagy. Antiviral Research 2018 Jul;155:28-38.

  21. Pinals RL, Ledesma F, Yang D, Navarro N, Jeong S, Pak JE, Kuo L, Chuang YC, Cheng YW, Sun HY, Landry MP. Rapid SARS-CoV-2 Spike Protein Detection by Carbon Nanotube-Based Near-Infrared Nanosensors. Nano Letters 2021 Mar 10;21(5):2272-2280.

  22. Tien SM, Chang PC, Lai YC, Chuang YC, Tseng CK, Kao YS, Huang HJ, Hsiao YP, Liu YL, Lin HH, Chu CC, Cheng MH, Ho TS, Chang CP, Ko SF, Shen CP, Anderson R, Lin YS, Wan SW, Yeh TM. Therapeutic efficacy of humanized monoclonal antibodies targeting dengue virus nonstructural protein 1 in the mouse model. PLoS Pathog. 2022 Apr 29;18(4):e1010469. doi: 10.1371/journal.ppat.1010469.

  23. Cheng YW, Chuang YC, Huang SW, Liu CC, Wang JR. An auto-antibody identified from phenotypic directed screening platform shows host immunity against EV-A71 infection. J Biomed Sci. 2022 Feb 8;29(1):10. doi: 10.1186/s12929-022-00794-2.

  24. Lai YC, Cheng YW, Chao CH, Chang YY, Chen CD, Tsai WJ, Wang S, Lin YS, Chang CP, Chuang WJ, Chen LY, Wang YR, Chang SY, Huang W, Wang JR, Tseng CK, Li CK, Chuang YC*, Yeh TM*. Antigenic Cross-Reactivity between SARS-CoV-2 S1-RBD and Its Receptor ACE2. Front. Immunol. Front Immunol. 2022 May 4;13:868724. * Corresponding author

  25. Cheng YL, Chao CH, Lai YC, Hsieh KH, Wang JR, Wan SW, Huang HJ, Chuang YC, Chuang WJ, Yeh TM. Antibodies Against the SARS-CoV-2 S1-RBD Cross-react with Dengue Virus and Hinder Dengue Pathogenesis. Front. Immunol. 2022 Aug 15;13:941923. doi: 10.3389/fimmu.2022.941923. eCollection 2022.

研討會論文

  1. Chuang YC, Yeh TM. (2012) Dengue virus-induced antibodies against thrombin and inhibit its activity. 15th International Congress of Infectious Diseases. (Bangkok, Thailand).
  2. Chiu CD, Chuang YC, Yeh TM. (2012) Establishment of secreted alkaline phosphatase (SEAP) reporter assay for Dengue virus titration. 15th International Congress of Infectious Diseases. (Bangkok, Thailand).
  3. Lin SW, Chuang YC, Yeh TM. (2012) Generation of anti-dengue nonstructural protein 1 monoclonal antibodies for early and rapid detection of dengue virus infection. 15th International Congress of Infectious Diseases. (Bangkok, Thailand).
  4. Yeh TM, Chuang YC. (2012) Inhibition of macrophage migration inhibitory factor reduces dengue virus replication in human hepatoma cells.10th Joint annual meeting of the international cytokine society and international society for interferon and cytokine research. (Geneva, Switzerland).
  5. Chuang YC, Yeh TM. (2012) Marcrophage migration inhibitory factor enhances dengue virus replication through autophagy formation and ROS generation. 99th Annual meeting of the American Association of Immunologists (Boston).
  6. Yeh TM, Chuang YC. (2012) Macrophage migration inhibitory factor induces autophagy via reactive oxygen species generation. 99th Annual meeting of the American Association of Immunologists (Boston).
  7. Yeh TM, Chuang YC. (2013) Antibodies against thrombin in dengue patients contain both anti-thrombotic and pro-fibrinolytic activities. The 3rd International Conference on Dengue/DHF (Bangkok, Thailand).

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