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王雅芳

王雅芳 助理教授  Ya-Fang Wang

 

  實驗室電話：3636-65222

  辦公室地點：台南市勝利路367號統一健康大樓5F

  電子信箱：anavon31@gmail.com

 

開授課程

大學部

  上學期︰無

  下學期︰臨床病毒學

碩士班

  上學期︰無

  下學期︰無

MyLab實驗室研究方向

  • 流行性感冒病毒醣類受體結合專一性研究
  • 登革熱與日本腦炎血清流行病學研究

指導學生

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指導學生之特殊榮譽

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榮譽及獎勵

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期刊論文

  • Yang Y H, Tai C H, Cheng Dayna, Wang Ya-Fang, Wang JR*. Investigation of Avian Influenza H5N6 Virus-like Particles as a Broad-Spectrum Vaccine Candidate against H5Nx Viruses. Viruses 2022 Apr 28;14(5):925.
  • Hung SJ, Tsai HP, Wang Ya-Fang, Ko WC, Wang JR, Huang SW*. Assessment of the Risk of Severe Dengue Using Intrahost Viral Population in Dengue Virus Serotype 2 Patients via Machine Learning. Front Cell Infect Microbiol. 2022 Feb 10;12:831281.
  • Huang SW, Tai CH, Hsu YM, Cheng D, Hung SJ, Chai KM, Wang Ya-Fang, Wang JR*. Assessing the application of a pseudovirus system for emerging SARS-CoV-2 and re-emerging avian influenza virus H5 subtypes in vaccine development. Biomed J. 2020 Aug;43(4):375-87.
  • Tsai YH, Huang SW, Hsieh WS, Cheng CK, Chang CF, Wang Ya-Fang, Wang JR*. Enterovirus A71 Containing Codon-Deoptimized VP1 and High-Fidelity Polymerase as Next-Generation Vaccine Candidate. J Virol. 2019 Jun 14;93(13):e02308-18.
  • Wang Ya-Fang, Chang CF, Tsai HP, Chi CY, Su IJ, Wang JR*. Glycan-binding preferences and genetic evolution of human seasonal influenza A(H3N2) viruses during 1999-2007 in Taiwan. PLoS One. 2018 May 10;13(5):e0196727.
  • Wang Ya-Fang, *. Molecular Epidemiology and Clinical Manifestations of Adenovirus Respiratory Infections in Taiwanese Children. 2016 May;95(18):e3577.
  • Lim MC, † Wang Ya-Fang, † Huang SW, Yang JY, Wang JR*. High incidence of mammalian orthoreovirus identified by environmental surveillance in Taiwan. Microbes and Environments. PLoS One. 2015 Nov 10;10(11):e0142745. (†Authors contributed equally)
  • Su PY, Wang Ya-Fang, Huang SW, Lo YC, Wang YH, Wu SR, Shieh DB, Chen SH, Wang JR, Lai MD, Chang CF*. Cell surface nucleolin facilitates enterovirus 71 binding and infection. J Virol. 2015 Apr 15;89(8):4527-38.
  • Chia MY, Hu AY, Tseng YF, Weng TC, Lai CC, Lin JY, Chen PL, Wang Ya-Fang, Chao SR, Chang JY, Hwang YS, Yeh CT, Yu CP, Chen YC, Su IJ, Lee MS*. Evaluation of MDCK Cell-Derived Influenza H7N9 Vaccine Candidates in Ferrets. PLoS One. 2015 Mar 23;10(3):e0120793.
  • Lee PH, Liu CM, Ho TS, Tsai YC, Lin CC, Wang Ya-Fang, Chen YL, Yu CK, Wang SM, Liu CC, Shiau AL, Lei HY, Chang CP*. Enterovirus 71 virion-associated galectin-1 facilitates viral replication and stability. PLoS One. 2015 Feb 23;10(2):e0116278.
  • Wang Ya-Fang, Yu CK*. Animal models of enterovirus 71 infection: applications and limitations. J Biomed Sci. 2014 Apr 17;21:31. Review.
  • Linsuwanon P, Puenpa J, Huang SW, Wang Ya-Fang, Mauleekoonphairoj J, Wang JR, Poovorawan Y*. Epidemiology and seroepidemiology of human enterovirus 71 among Thai populations. J Biomed Sci. 2014 Feb 18;21(1):16.
  • Chou AH, Liu CC, Chang JY, Jiang Renee, Hsieh YC, Tsao Amanda, Wu CL, Huang JL, Fung CP, Hsieh SM, Wang Ya-Fang, Wang JR, Hu MH, Chiang JR, Su IJ, Chong PC*. Formalin-inactivated EV71 vaccine candidate induced cross-neutralizing antibody against subgenotypes B1, B4, B5 and C4A in adult volunteers. PLoS One. 2013 Nov 21;8(11):e79783.
  • Hung CH, Yang SN, Wang Ya-Fang, Liao WT, Kuo PL, Tsai EM, Lee CL, Chao YS, Yu HS, Huang SK, Suen JL*. Environmental alkyphenols modulate cytokine expression in plasmacytoid dendritic cells. PLoS One. 2013 Sep 11;8(9):e73534.
  • Thoa le PK, Chiang PS, Khanh TH, Luo ST, Dan TN, Wang Ya-Fang, Thuong TC, Chung WY, Hung NT, Wang JR, Nhan le NT, Thinh le Q, Su IJ, Dung TD, Lee MS*. Genetic and antigenic characterization of enterovirus 71 in Ho Chi Minh City, Vietnam, 2011. PLoS One. 2013 Jul 29;8(7):e69895.
  • Lee YP, Wang Ya-Fang, Wang JR, Huang SW, Yu CK*. Enterovirus 71 blocks selectively type I interferon production through the 3C viral protein in mice. J Med Virol. 2012 Nov;84(11):1779-89.
  • Su PY, Liu TY, Chang HY, Huang SW, Wang Ya-Fang, Yu CK, Wang JR, Chang CF*. Cell surface sialylation affects binding of enterovirus 71 to rhabdomyosarcoma and neuroblastoma cells. BMC Microbiology 2012 Aug 1; 12:162.
  • Wang Ya-Fang, Chang CF, Chi CY, Wang HC, WangJR, Su IJ*. Characterization of glycan binding specificities of Influenza B viruses with correlation with hemagglutinin genotypes and clinical features. J Med Virol. 2012 Apr;84(4):679-85.
  • Wang Ya-Fang, Lao WI, Kuo YD, Guu SY, Wang HC, Lin CH, Wang JR, Su IJ, Chang CF*. Receptor binding surveillance of influenza clinical isolates. Future Virol 2012; 7(6): 621-33.
  • Huang SW, Wang Ya-Fang, Yu CK, Su IJ, Wang JR*. Mutations in VP2 and VP1 capsid proteins increase infectivity and mouse lethality of enterovirus 71 by virus binding and RNA accumulation enhancement. Virology. 2012 Jan 5;422(1):132-43.
  • Chen CW, Lee YP, Wang Ya-Fang, Yu CK*. Formaldehyde-inactivated human enterovirus 71 vaccine is compatible for co-immunization with a commercial pentavalent vaccine. Vaccine 2011 Mar, 29 (15):2772-6.
  • Lao WI, Wang Ya-Fang, Kuo YD, Lin CH, Chang TC, Su IJ, Wang JR, Chang CF*. Profiling of influenza viruses by high-throughput carbohydrate membrane array. Future Med Chem 2011 Mar, 3 (3):283-96.
  • Wong TW, Huang HJ, Wang Ya-Fang, Lee YP, Huang CC, Yu CK*. Methylene blue-mediated photodynamic inactivation as a novel disinfectant of enterovirus 71. J Antimicrob Chemother 2010, Oct;65(10):2176-82.
  • Wu T C, Wang Ya-Fang, Lee YP, Wang JR, Liu CC, Wang SM, Lei HY, Su IJ, Yu CK*. Immunity to avirulent enterovirus 71 and Coxsackie A16 virus protect enterovirus 71 infection in mice. J Virol 2007 Oct;81(19):10310-5.
  • Chen CS, Yao YC, Lin SC, Lee YP, Wang Ya-Fang, Wang JR, Liu CC, Lei HY, Yu CK*. Retrograde axonal transport: the major transmission route of enterovirus 71 in mice. J Virol 2007 Sep;81(17):8996-9003.
  • Liu ML, Lee YP, Wang Ya-Fang, Lei HY, Liu CC, Wang SM, Su IJ, Wang JR, Yeh TM, Chen SH, Yu CK*. Type I interferons protect mice against enterovirus 71 infection. J Gen Virol 2005 Dec;86(Pt 12):3263-69.
  • Wang Ya-Fang, Chou CT, Lei HY, Liu CC, Wang SM, Yan JJ, Su IJ, Wang JR, Yeh TM, Chen SH, Yu CK*. A mouse-adapted enterovirus 71 strain causes neurological disease in mice after oral infection. J Virol 2004 Aug;78(15):7916-24.
  • Chen YC, Yu CK, Wang Ya-Fang, Liu CC, Su IJ, Lei HY*. A murine oral enterovirus 71 infection model with central nervous system involvement. J Gen Virol 2004 Jan;85(Pt 1):69-77.
  • 郭世文、吳佩修、王裕宏、王雅芳、劉韋良、陳佳靖。科學博物館協力公眾參與科學之實踐-以沃爾巴克氏菌防治登革熱展示為例。臺灣衛誌 2022；41(2)：211-225。

研討會論文

  • Ya-Fang Wang, Sheng-Wen Huang, Piyada Linsuwanon, Yoke-Fun Chan, Yong Poovorawan and Jen-Ren Wang. Antigenic Variations among Enterovirus 71 Genotypes by Using Human Antisera from Different Countries. The 32nd annual meeting of the American Society for Virology (ASV), 2013, Pennsylvania, U.S.A.
  • Ya-Fang Wang, Sheng-Wen Huang, Jen-Ren Wang, Huan-Yao Lei, and Chun-Keung Yu. Multiple amino acid variations of enterovirus 71 alter its in vitro phenotypes and virulence in mice during mouse brain adaptation. International Symposium on Infectious Disease and Signal Transduction-Taiwan-Japan Joint Symposium on Cell Signaling and Gene Regulation-Professor Huan-Yao Lei Memorial Symposium, 2012, Tainan, Taiwan.
  • Ya-Fang Wang, Chia-Yu Chi, Chuan-Fa Chang, Hsuan-Chen Wang, Jen-Ren Wang, Ih-Jen Su. Hemagglutinin Receptor Binding Preferences of Recent Influenza A Viruses in Taiwan. International Society for Influenza and other Respiratory Virus Diseases: isirv--'Severe Influenza: Burden, Pathogenesis and Management', 2012, Hanoi, Viet Nam.
  • Ya-Fang Wang, Chia-Yu Chi, Chuan-Fa Chang, Hsuan-Chen Wang, Jen-Ren Wang, Ih-Jen Su. Different receptor binding preference of influenza A/H3N2 and B viruses correlated with clinical presentations and epidemiology. Keystone symposia on Molecular and Cellular Biology Pathogenesis of Influenza: Virus-Host Interactions (E3). 2011, Hong Kong, China. (Received Scholarship award).
  • Ya-Fang Wang, Chia-Yu Chi, Chuan-Fa Chang, Hsuan-Chen Wang, Jen-Ren Wang, Ih-Jen Su. Exploring the carbohydrate receptor binding specificity of swine H1N1 and seasonal influenza viruses in Taiwan. Options for Control of Influenza VII, 2010, Hong Kong, China.
  • Ya-Fang Wang, Chia-Yu Chi, Chuan-Fa Chang, Hsuan-Chen Wang, Jen-Ren Wang, and Ih-Jen Su. Clinical phenotype and glycan biology of Influenza B in Taiwan. The 3rd International Conference on Influenza Vaccines for the World, 2009, Cannes, France.

研究計畫

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主辦、參與國際會議

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