陳怡伶 副教授  Yi-Lin Chen

  辦公室地點：成大醫院 病理部 分子診斷

  電子信箱：emerald@mail.ncku.edu.tw

開授課程

• Molecular Diagnosis Technology/ Techniques in Molecular Diagnosis、Molecular diagnosis in HLA Typing
• Clinical Cytogenetics and Molecular Genetics Rotations
• Hematology /Molecular Diagnosis in Hematology
• 醫學生物技術概論/次世代定序在生物醫學的應用
• 實驗診斷概論/分子診斷
• 臨床生化實驗/ CYP2C9*1/*3

實驗室研究方向

• 組織相容抗原與抗體分型
• 器官移植符合配對
• 白血病與淋巴癌之分子診斷
• 癌症基因相關研究
• 次世代基因定序: 菌相分析 (Metagenomics)及癌症基因組 (Cancer Panel)

指導學生

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指導學生之特殊榮譽

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榮譽及獎勵

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期刊論文

1. Yi-Lin Chen, Chien-Chung Lin, Yu-Ting Yu, Wan-Li Chen, Shu-Ching Yang, Wenya Huang, Wu-Chou Su, Nan-Haw Chow, Chung-Liang Ho. (2023, Nov). Clinical Implication of PNA-Sequencing as a Complementary Test for EGFR Mutation Analysis in Human Lung Cancers. Oncology Letters, 26: 539.

2. Hui-Ching Cheng, Po-Hsien Huang, Feng-Jie Lai, Ming-Shiou Jan, Yi-Lin Chen, Szu-Ying Chen, Wan-Li Chen, Chao-Kai Hsu, Wenya Huang, Li-Jin Hsu (2023, Oct). Loss of fragile WWOX gene leads to senescence escape and genome instability. Cell Mol Life Sci. , 2023 Oct 28; 80 (11): 338.

3. Tsunglin Liu, Cheng-Han Lin, Yi-Lin Chen, Chien-Cheng Yeh, Yuan-Yow Chiou, Jiu-Yao Wang, Chung-Ta Lee, Kuo-Ting Lee, Ai-Li Shiau, Chao-Liang Wu, Jui-Wen Kang, Po-Jun Chen, Hsin-Yu Kuo, Er-Hsiang Yang, Chiao-Hsiung Chuang. (2023, Sep). Relationship between rectal swab and tissue samples in the analysis of mucosa-associated microbiota in patients with inflammatory bowel disease. Inflammatory Bowel Disease, 2023,1–12.

4. Chen Chang, Yi-Lin Chen(co-first authors), Yi-Wen Wang, Hui-Wen Chen, Che-Wei Hsu, Kun-Che Lin, Yin-Chien Ou, Tsung Lin Liu, Wan-Li Chen, Chien Chu, Chung-Liang Ho, Chung-Ta Lee and Nan-Haw Chow (2023, Jul). Aberrant trophoblastic differentiation in human cancer: An emerging novel therapeutic target. Oncology Reports, OR-293449: DOI: 10.3892.

5. Yu-Ting Yu, Kuan-Yu Lin, Ya-Ping Chen, Yi-Lin Chen, L. Jeffrey Medeiros, Kung-Chao Chang (2023, Jul). TdT-positive high-grade B-cell lymphoma with BCOR and IDH1 mutations. Pathology, 2023.05.013.

6. Wenya Huang, Chung-Liang Ho, Chung-Ta Lee, Wan-Li Chen, Shu-Ching Yang, Nan-Haw Chow, Yi-Lin Chen (2023, Mar). High concordance rate of capillary electrophoresis workflow for microsatellite instability analysis and mismatch repair (MMR) immunostaining in colorectal carcinoma. PLoS One, 18(4): e0284227.

7. Yi-Lin Chen, Chung-Liang Ho, Chen-Yan Hung, Wan-Li Chen, Chen Chang, Yi-Hsin Hou, Jian-Rong Chen, Pin-Jun Chen, Nan-Haw Chow, Wenya Huang, Ya-Ting Hsu, Tsai-Yun Chen, Tsunglin Liu. (2022, Dec). Enhancing diagnosis of Tcell lymphoma using non-recombined T-cell receptor sequences. Frontier in Oncology, 12:1014132.

8. Chien-Yu Lin, Sheng-Huan Wei, Yi-Lin Chen, Chung-Ta Lee, Shang-Yin Wu, Chung-Liang Ho, Dean C. Pavlick, Po-Lan Su and Chien-Chung Lin (2022, Aug). Case report: Salvage capmatinib therapy in KIF5B-MET fusion-positive lung adenocarcinoma with resistance to telisotuzumab vedotin. Frontiers in Oncology, 12:919123-9.

9. Szu-Chun Yang, Chien-Chung Lin, Yi-Lin Chen and Wu-Chou Su (2022, May). Economic Analysis of Tissue-First, Plasma-First, and Complementary NGS Approaches for Treatment-Naive Metastatic Lung Adenocarcinoma. Frontiers in Oncology, 12:873111-873119.

10. Szu-Chun Yang, Yi-Chen Yeh, Yi-Lin Chen, and Chao-Hua Chiu (2022, Apr). Economic analysis of exclusionary EGFR testing versus upfront next-generation sequencing for metastatic lung adenocarcinoma in high EGFR mutation prevalence areas. Journal of the National Comprehensive Cancer Network, 4:7120-7134.

11. Tsunglin Liu, Cheng-Han Lin, Yi-Lin Chen, Shuen-Lin Jeng, Hui-Ju Tsai, Chung-Liang Ho, Wen-Shuo Kuo, Miao-Hsi Hsieh, Pei-Chi Chen, Lawrence Shih-Hsin Wu and Jiu-Yao Wang. (2022, Mar). Nasal Microbiome Change During and After Exacerbation in Asthmatic Children. Frontiers in Microbiology, Volume 12: Article 833726-833736.

12. Po-Lan Su, Jung-Yueh Chen, Chang-Yao Chu, Yi-Lin Chen, Wan-Li Chen, Kuan-Yu Lin, Chung-Liang Ho, Jeng-Shiuan Tsai, Szu-Chun Yang, Chian-Wei Chen, Yi-Lin Wu, Yau-Lin Tseng, Chao-Chun Chang, Yi-Ting Yen, Chia-Ying Lin, Chien-Chung Lin, Wu-Chou Su. (2022, Feb). The impact of driver mutation on the treatment outcome of early-stage lung cancer patients receiving neoadjuvant immunotherapy and chemotherapy. Scientific Reports, (2022)12:3319-3328.

13. Chien-An Chu , Yi-Wen Wang , Yi-Lin Chen(co-first authors), Hui-Wen Chen , Jing-Jing Chuang , Hong-Yi Chang , Chung-Liang Ho, Chen Chang, Nan-Haw Chow and Chung-Ta Lee. (2021, Oct). The Role of Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 in the Pathogenesis of Human Cancer. Internal journal of molecular science, 22, 10964.

14. Chen YL, Chen WL, Cheng YC, Lin MC, Yang SC, Tsai HW, Lin CC, Su WC, Chow NH, Ho CL. (2021, Sep). Development of a novel ALK rearrangement screening test for non-small cell lung cancers . PLoS One, 24;16(9):e0257152.

15. Su PL, Lin CY, Chen YL, Chen WL, Lin CC, Su WC. (2021, Jun). Durable Response to Combined Dabrafenib and Trametinib in a Patient With BRAF K601E Mutation-Positive Lung Adenocarcinoma: A Case Report. JTO Clin ResRep, 3;2(8):100202.

 16. Lee Jenq chang, Nan-Haw Chow, Yi-Lin Chen, Chung-Liang Ho, Yu-Min Yeh, Shao-Chieh Lin, Peng-Chan Lin, Bo-Wen Lin, Chien-An Chu, Hung-Wen Tsai. (2021, Jan). Clinicopathological features of mismatch repair protein expression patterns in colorectal cancer. Research and Practice, 217: 153288.

17. Tsunglin Liu, Chen-Yu Chen, An Chen-Deng, Yi-Lin Chen, Jiu-Yao Wang, Yung-I Hou and Min-Ching Lin. (2020, Oct). Joining Illumina paired-end reads for classifying phylogenetic marker sequences. BMC Bioinformatics, 2020 Mar 14; 21(1):105-118.

18. Tu M, Cheng J, Chen YL, Jea WC, Chen WL, Chen CJ, Ho CL, Huang WL, Lin CC, Su WC, Ye Q, Deignan J, Grody W, Li F, Chia D, Wei F, Liao W, Wong DTW, Strom CM. (2020, Aug). Electric Field-Induced Release and Measurement (EFIRM): Characterization and Technical Validation of a Novel Liquid Biopsy Platform in Plasma and Saliva. The Journal of Molecular Diagnostics, 22: 8: 1050-1062.

19. Yu-Hung Lin, Sheng-Jou Hung, Yi-Lin Chen, Cheng-Han Lin, Te-Fang Kung, Yi-Chun Yeh, Joseph T. Tseng, Tsunglin Liu (2020, Jul). Dissecting efficiency of a 5’rapid amplification of cDNA ends (5’-RACE) approach for profiling T-cell receptor beta repertoire. PLoS ONE, 15(7): e0236366.

20. Yu-Min Yeh,Chun-Hui Lee, Shang-Hung Chen,Chung-Ta Lee, Yi-Lin Chen, Bo-Wen Lin, Shao-Chieh   Lin, Ren-Hao Chan, Jenq-Chang Lee, Meng-Ru Shen, Peng-Chan Lin. (2019, Aug). Comprehensive assessment of HER2 alteration in a colorectal cancer cohort: from next-generation sequencing to clinical significance. Cancer Management and Research, 11: 7867–7875.

21. Po‐Lan Su, Szu‐Chun Yang,Yi‐Lin Chen(co-first authors),Yi‐Lin Wu,Chia‐Ying Lin, Wei‐Yuan Chang,Yau‐Lin Tseng,Wu‐Wei Lai,Chung‐Liang Ho,Chien‐Chung Lin,Wu‐Chou Su. (2019, Jul). Real‐world outcomes of NSCLC patients receiving tissue or circulating tumor DNA‐guided osimertinib treatment. Cancer Medicine, 2019 Oct; 8(13): 5939-5947.

22. Yi-Lin Chen, Chien-Chung Lin, Shu-Ching Yang, Wan-Li Chen, Jian-Rong Chen, Yi-Hsin Hou, Cheng-Chan Lu, Nan-Haw Chow, Wu-Chou Su and Chung-Liang Ho. (2019, Jul). Five technologies for detecting the EGFR T790M mutation in the circulating cell-free DNA of patients with non-small cell lung cancer: a comparison. Frontier oncology, 2019 July, vol 9 (631): 1-8.

23. Chia-Jui Yen, Yu-Lin Ai, Hung-Wen Tsai, Shih-Huang Chan, Chia-Sheng Yen, Kuang-Hsiung Cheng, Yun-Ping Lee, Chia-Wei Kao, Yu-Chun Wang, Yi-Lin Chen, Cheng-Han Lin, Tsunglin Liu, Huey-Pin Tsai, Jen-Ren Wang, Ih-Jen Su, and Wenya Huang (2018, Jan). Hepatitis B virus surface gene pre-S2 mutant as a high-risk serum marker for hepatoma recurrence after curative hepatic resection. Hepatology, 68 (3): 815-826.

二、專書

1. 陳怡伶，黃溫雅（2023年09月）醫學分子檢驗: 章節:藥物基因體學之分子診斷 (Pharmacogenomics   in Molecular Diagnosis)（ISBN：978-626-366-564-4）（第七版）。台灣：五南圖書出版公司。

2. 陳怡伶，黃溫雅（2023年03月）醫學檢驗品質管理: 章節: 醫學分子檢驗

實驗室的品質管理(Quality Mangement in Molecular Diagnostic Laboratory)（ISBN：978-626-343-396-0）（第二版）。台灣：五南圖書出版公司。

研討會論文

• Yi-Lin Chen, Chung-Ta Lee, Cheng-Chan Lu, Shu-Ching Yang, Wan-Li Chen, Yang-Cheng Lee, Chung-Hsien Yang, Shu-Ling Peng, Wu-Chou Su, Nan-Haw Chow, Chung-Liang Ho. Epidermal Growth Factor Receptor Mutation and Anaplastic Lymphoma Kinase Gene Fusion: Detection in Malignant Pleural Effusion by RNA or PNA Analysis. 2017醫檢年會(2017亞培優秀論文獎)
• 陳怡伶、林雅嵐、林旻靜、劉宗霖、黃溫雅、何中良.利用次世代基因定序分析台灣地區T細胞淋巴瘤個體之T細胞受體基因組合. 2013年第六屆亞太醫學檢驗科學國際研討會.(2013優秀口頭論文獎)
• 林雅嵐、陳怡伶、李權君、劉宗霖、何中良、顏經洲.次世代定序技術分析微生物菌群. 2013年第六屆亞太醫學檢驗科學國際研討會.(2013優秀口頭論文獎)
• 陳菀莉、陳怡伶、張孔昭、何中良、顏經洲.建立EML4-ALK檢測技術於肺癌病患之經驗分享.2013年第六屆亞太醫學檢驗科學國際研討會
• 林旻靜、陳怡伶、林雅嵐、陳菀莉、何中良.以FISH方法評估非小細胞腺癌之ALK轉位. 2013年醫檢年會
• 李權君、陳怡伶、林雅嵐、何中良、劉宗霖.Increasing the lengths of 16S rDNA sequences for accurate identification of bacterial species in dioxin containing samples. 2013年ISEGB
• Yi-Lin Chen (陳怡伶), Wen-Ya Huang（黃溫雅）, Chung-Liang Ho (何中良), Wu-Chou Su (蘇五洲), Cheng-Chan Lu (呂政展). EGFR Mutation Analysis in Non-Small Cell Lung Cancers (NSCLC): Experience from a southern Taiwan molecular diagnosis core center (2011, Associated Molecular Pathology AMP annual meeting)
• Yi-Lin Chen (陳怡伶), Yu-Min Yeh (葉裕民), Tsai-Yun Chen(陳彩雲), Chung-Liang Ho(何中良).High Percentage of JAK2 Exon 12 Mutation in Asian Patients with Polycythemia Vera (2010, Associated Molecular Pathology AMP annual meeting)

研究計畫

院內計劃: 每年約一件

主辦、參與國際會議

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教學、研究國際交流

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