個人資料

2018/04/29

蔡慧頻 臨床助理教授
Huey-Pin Tsai
實驗室電話：2653
辦公室地點：成大醫院病理部臨床病毒實驗室
電子信箱： tsaihp@mail.ncku.edu.tw

開授課程

學歷

經歷

實驗室研究方向

歷年實驗室研究成員

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榮譽及獎勵

專利

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技術轉移

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期刊論文

  • Yen CJ, Ai YL, Tsai HW, Chan SH, Yen CS, Cheng KH, Lee YP, Kao CW, Wang YC, Chen YL, Lin CH, Liu T, Tsai HP, Wang JR, Su IJ, Huang W. 2018 Jan Hepatitis B virus surface gene pre-S2 mutant as a high-risk serum marker for hepatoma recurrence after curative hepatic resection. Hepatology. 2018 Jan 19.
  • Huang SW, Huang YH, Tsai HP, Kuo PH, Wang SM, Liu CC, Wang JR. 2017 Sep. A selective bottleneck shapes the evolutionary mutant spectra of enterovirus A71 during viral dissemination in humans. J Virol. 20. pii: JVI.01062-17.
  • Tsai HP, Tsai YY, Lin IT, Kuo PH, Chang KC, Chen JC, Ko WC, Wang JR. 2016 Oct. Validation and Application of a Commercial Quantitative Real-Time Reverse Transcriptase-PCR Assay in Investigation of a Large Dengue Virus Outbreak in Southern Taiwan. PLoS Negl Trop Dis. 12;10(10):e0005036.
  • Tsai HP, Tsai YY, Lin IT, Kuo PH, Chen TY, Chang KC, Wang JR. 2016 Aug. Comparison of Two Commercial Automated Nucleic Acid Extraction and Integrated Quantitation Real-Time PCR Platforms for the Detection of Cytomegalovirus in Plasma. PLoS One. 5;11(8):e0160493.
  • Wang YF, Shen FC, Wang SL, Kuo PH, Tsai HP, Liu CC, Wang JR, Chi CY. 2016 May. Molecular Epidemiology and Clinical Manifestations of Adenovirus Respiratory Infections in Taiwanese Children. Medicine (Baltimore).;95(18):e3577.
  • Huang SW, Cheng HL, Hsieh HY, Chang CL, Tsai HP, Kuo PH, Wang SM, Liu CC, Su IJ, Wang JR. 2014 Apr. Mutations in the non-structural protein region contribute to intra-genotypic evolution of enterovirus 71. J Biomed Sci. 26;21(1):33.
  • Wang SL, Chi CY, Kuo PH, Tsai HP, Wang SM, Liu CC, Su IJ, Wang JR. High-incidence of human adenoviral co-infections in Taiwan. PLoS One. 2013 Sep 20;8(9):e75208.
  • Tsai HP, Huang SW, Wu FL, Kuo PH, Wang SM, Liu CC, Su JJ, Wang JR. An echovirus 18-associated outbreak of aseptic meningitis in Taiwan: epidemiology and diagnostic and genetic aspects. J. Med. Microbiol. 2011 Sep; 60(pt9):1360-5.
  • Tsai HP, Wang JR. 2011. Influenza viruses and 2009 H1N1 pandemic influenza virus. Formosan J Med 15(3): 252-260 (invited review).
  • Huang SW, Hsu YW, Smith DJ, Kiang D, Tsai HP, Lin KH, Wang SM, Liu CC, Su IJ, Wang JR. Reemergence of enterovirus 71 in 2008 in taiwan: dynamics of genetic and antigenic evolution from 1998 to 2008.J. Clin. Microbiol. 2009 Nov;47(11):3653-62.
  • Wang HC, Huang SW, Wang SW, Tsai HP, Kiang D, Wang SM, Liu CC, Su IJ, Wang JR. Co-circulating genetically divergent A2 human metapeumovirus strains among children in southern Taiwan. 2008 Arch Virol. 153:2207-2213.
  • Huang SC, Hsu YW, Wang HC, Huang SW, Kiang D, Tsai HP, Wang SM, Liu CC, Lin KH, Su IJ, Wang JR. Appearance of intratypic recombination of enterovirus 71 in Taiwan from 2002 to 2005. Virus Res. 2008 Feb;131(2):250-9.
  • Tsai HP, Wang HC, Kiang D, Huang SW, Kuo PH, Liu CC, Su IJ, Wang JR. Increasing appearance of reassortant influenza B virus in Taiwan from 2002 to 2005. J. Clin Microbiol. 2006 Aug;44(8):2705-13.
  • Wang JR, Tsai HP, Huang SW, Kuo PH, Kiang D, Liu CC. Laboratory diagnosis and genetic analysis of an echovirus 30-associated outbreak of aseptic meningitis in Taiwan in 2001.J Clin Microbiol. 2002 Dec;40(12):4439-44.
  • Wang JR, Tuan YC, Tsai HP, Yan JJ, Liu CC, Su IJ. Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000. J Clin Microbiol. 2002 Jan;40(1):10-5.
  • Shan YS, Lee PC, Wang JR, Tsai HP, Sung CM, Jin YT. Fibrosing cholestatic hepatitis possibly related to persistent parvovirus B19 infection in a renal transplant recipient. Nephrol Dial Transplant. 2001 Dec;16(12):2420-2.
  • Tsai HP, Kuo PH, Liu CC, Wang JR. Respiratory viral infections among pediatric inpatients and outpatients in Taiwan from 1997 to 1999. J Clin Microbiol. 2001 Jan;39(1):111-8.
  • Wang JR, Tsai HP, Chen PF, Lai YJ, Yan JJ, Kiang D, Lin KH, Liu CC, Su IJAn outbreak of enterovirus 71 infection in Taiwan, 1998. II. Laboratory diagnosis and genetic analysis. .J Clin Virol. 2000 Aug;17(2):91-9.

研討會論文

  • Tsai HP, Lin IT, Yeh CS, Tsai YY, Wang JR. 2018. Rapid and ELISA tests for dengue diagnosis during dengue virus type 2 epidemic in TAIWAN. ASM Clinical Virology Symposium, May 6-9. West Palm beach, Florida, USA.
  • Tseng CJ, Tsai HP, Kuo PH, Tsai YY, Lin IT, Jen-Ren Wang JR. 2018. Improve the effectiveness of reporting in viral isolation for monitoring community viral activity by PDCA strategy. The 9th Asia-Pacific Forum of Medical Laboratory Science. April 14-16. Kaohsiung.
  • Tsai HP、Kuo JY、Wang JR. 2017. Wang Analysis of antiviral resistance of herpes simplex virus from recurrent infections. The 9th Asia-Pacific Forum of Medical Laboratory Science. Taoyuan, Taiwan, April 15-16.
  • Ko CY, Tsai HP, Kuo PH, Lin IT, Cai YY, Tsai HN, Hou CM, Chang KC, Wang JR. 2017. Analysis of Influenza Virus Epidemics, Severe and Death Cases from 2015 to 2016. The 9th Asia-Pacific Forum of Medical Laboratory Science. Taoyuan, Taiwan, April 15-16.
  • Lin IT, Tsai HP, Tsai YY, Ko CY, Tsai HN, Hou CM, Chang KC, Wang JR. 2017. Evaluate InBios Dengue NS1 DetectTM Kit for Detection of Dengue NS1 Antigen. The 9th Asia-Pacific Forum of Medical Laboratory Science. Taoyuan, Taiwan, April 15-16.
  • Tsai HP , Tsai YY, Kuo PH, Lin IT, Ko CY, Tsai HN, Chen JC, Chang KC ,WC Ko, Wang JR. 2016. Validation and Application of a Commercial Quantitative Real-Time Reverse Transcriptase-PCR Assay in Investigation of a Large Dengue Virus Outbreak in Southern Taiwan. The 2016 annual meeting of the Chinese Society of Medical Technology, Taipei, Nov. 26-27.
  • Tsai HP , Tsai YY, Kuo PH, Lin IT, Ko CY, Tsai HN, Chen JC, Chang KC ,Chen TY, Wang JR. 2016. Establish standardized cytomegalovirus viral load assays for monitoring treatment outcome in bone marrow or hematopoietic stem cell transplant recipients. The 8th Asia-Pacific Forum of Medical Laboratory Science. Taichung, Taiwan, April 16-17.
  • Lin IT, Tsai HP, Kuo PH, Tsai YY, Ko CY, Tsai HN, Chang KC, Wang JR. 2016. Molecular epidemiology analysis of Echovirus in a cluster outbreak of aseptic meningitis. The 8th Asia-Pacific Forum of Medical Laboratory Science. Taichung, Taiwan, April16-17.
  • Tsai HP, Kuo PH, Tsai YY, Lin IT, Ko CY, Tsai HN, Chang KC, Wang JR. 2015. Evaluation of commercial In Vitro Diagnostics Dengue virus antibody rapid test. The 24th annual meeting of Taiwan Society of Microbiology, Taipei, Taiwan, Dec 14-15.
  • Tsai HP, Kuo PH, Tsai YY, Lin IT, Ko CY, Tsai HN, Yan JJ, Wang JR. 2014. Comparison of Two Automated and Standardized CMV Viral Load Assays. Cross-strait laboratory medicine symposium in 2014. Aug 23~24.
  • Cai YY, Tsai HP, Kuo PH, Lin IT, Ko CY, Yan JJ, Wang JR. 2013. Respiratory syncytial virus infections among young children from 2009 to 2013 in southern Taiwan. The 22th annual meeting of Taiwan Society of Microbiology, Taipei, Taiwan, Dec 14-15.
  • Ko CY, Tsai HP, Kuo PH, Lin IT, Cai YY, Yan JJ, Wang JR.2013.Evaluation of Commercial Assays for Detection of Toxigenic Clostridium difficile Toxin in Stool Specimens.2013 3rd International Symposium on Infectious Disease and Signal Transduction, Tainan, Taiwan, Nov 16-17.
  • Tsai HP, Lin IT, Kuo PH, Ko CY, Cai YY, Yan JJ, Wang JR. 2013. Evaluation of commercial realtime PCR assays for quantification of Epstein-Barr virus DNA in plasma. The 2013 annual meeting of the Chinese Society of Medical Technology, Taipei, Nov. 2-3.
  • Wang SL, Kuo PH, Tsai HP, Wang JR. 2013., High incident adenoviral co-infections along with repeated infections revealed via a decade of molecular epidemiology study. The 32nd annual meeting of the American Society for Virology, The Pennsylvania State University, July 20-24.
  • Wang JR, Chang CL, Tai CH, Kuo PH, Tsai HP. 2013. Molecular epidemiology of enterovirus 71 from 1998 to 2012 in Taiwan. The 32nd annual meeting of the American Society for Virology, The Pennsylvania State University, July 20-24.
  • Hung SJ, Huang SW, Tsai HP, Kuo PH, Wang JR. 2013. Epidemiology and genetic analysis of 2009 pandemic H1N1 influenza viruses from 2009 to 2012 in Taiwan. The 29th Clinical Virology Symposium, Daytona Beach, Florida, April 26- May 1.
  • 郭品樺、蔡慧頻、柯喬云、蔡涵年、蔡侑遠、林怡婷、王貞仁。2012。以One-step RT-PCR法偵測諾羅病毒並進行基因分型。台灣檢驗醫學發展協會，高雄，台灣，10月20、21日。
  • Lin YT, Tsai HP, Kuo PH, Lin CW, Wang JR. 2012. Analysis of coxsackievirus A9 isolated from 2007 to 2011. The 2012 annual meeting of the Taiwan Society of Laboratory Medicine, Taipei, Taiwan, Nov. 4.
  • Tsai HP, Wang SY, Kuo PH, Ko CW, Kung YH, Yan JJ, Wang JR. 2011. Evaluation of different rapid molecular diagnosis methods in detection of pandemic influenza type A virus (pH1N1). Forth Asia-Pacific City Forum of Biomedical Laboratory Science. Tainan, Taiwan. April 30-May 1. Received Distinguished Paper Award-Poster Presentation.
  • Kung YH, Kuo PH, Tsai HP, Ko CW, Wang SY, Chien ML, Chen HM, Yan JJ, Wang JR. 2011. Reduction in the overall contamination rate for virus culture. 4th Asia-Pacific City Forum of Biomedical Laboratory Science, Tainan, Taiwan, April 30-May 1.
  • Tsai HP, Wang SY, Ko CW, Kuo PH, Kung YH, Yan JJ, Wang JR. Oct. 2010. Evaluation of two realtime PCR systems in detection of influenza A and B viruses in 2010. Cross-strait laboratory medicine symposium in 2010. Tainan, Taiwan, Oct 30-31.
  • Kuo PH, Wang SY, Tsai HP, Kung YH, Ko CW, Lee PC, Lin YJ, Wang JR. Establishment of a routine monitoring assay of polyomavirus BK in a clinical laboratory. Cross-strait laboratory medicine symposium in 2010. Tainan, Taiwan, Oct 30-31.
  • Kung YH, Tsai HP, Kuo PH, Wang SY, Ko CW, Yan JJ, Wang JR, Nov 2009, Evaluation of two rapid antigen tests for detection of influenza virus. Taiwan Society of Laboratory Medicine. Taipei, Taiwan, Nov 8.
  • Tsai HP, SY Wang, PH Kuo, YH Kung, Yan JJ, Wang JR. 2009. Evaluation of two commercial respiratory virus screening kits for identification of respiratory viruses in winter season of 2008-2009. The Asia-Pacific Medical Laboratory Science Forum, Kaohsiung, Taiwan, May 2-3.
  • Tsai HP, Wu FL, Huang SW, Kuo PH, Liu CC, Wang JR. 2007. Laboratory diagnosis and genetic analysis of echovirus 18 associated aseptic meningitis in Taiwan in 2006. The 23th Annual Clinical Virology Symposium and annual meeting Pan American Society for Clinical Virology, Clearwater Beach, Florida, April 29- May 2.
  • Tsai HP, Wu FL, Huang SW, Liu CC, Wang JR. 2006. Typing and genetic analysis of echovirus 18 associated aseptic meningitis in Taiwan in 2006. The 40th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Nov. 18.
  • Wang JR, Tsai HP, Huang SW, Kuo PH, Liu CC. 2005. Genetic and antigenic characterization of influenza B viruses isolated in Taiwan from 1998 to 2004. XIII international congress of virology. San Francisco, California, July 23-28.
  • Wang JR, Huang SW, Tsai HP, Kuo PH. 2004. Molecular analysis of an echovirus 6 associated outbreak of aseptic meningitis. The 20th Annual Clinical Virology Symposium, Clearwater Beach, Florida, April 25- 28.
  • Tsai HP, Chou WP, Shuh YW, Kuo PH, Wang JR. 2003. Comparison of three commercial rapid diagnosis kit and realtime RT-PCR for rapid detection of influenza virus from clinical specimens. The 37th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Dec.
  • Tsai HP, Tsai SW, Kuo PH, Liu CC, Wang JR. 2003. Screening of amatadine-resistant influenza A virus in southern Taiwan. Current status and challenge of infectious disease in Asia, Tainan, Taiwan.
  • Tsai HP, Huang SW, Kuo PH, Wang JR. 2002. Molecular evolution of influenza A/H3N2 viruses in southern Taiwan during 1999-2002. The 36th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Dec. 15.
  • Huang SW, Tsai HP, Kuo PH, Wang JR. 2002. Analysis of echovirus 6 associated with outbreak of aseptic meningitis in Taiwan in 2001. The 2002 annual meeting of the Chinese Society of Medical Technology, Taipei, Taiwan, Nov. 3.
  • Wang JR, Tsai HP, Huang SW, Kuo PH, Liu CC. 2002. Molecular analysis of echovirus 30 associated with outbreak of aseptic meningitis in Taiwan in 2001. XIIth International Congress of Virology, Paris, France, July 27-Aug. 1.
  • Wang JR, Tsai HP, Huang SW, Kuo PH. 2002. Echovirus 30 associated with outbreak of aseptic meningitis in Taiwan in 2001. The 18th Clinical Virology Symposium, Clearwater Beach, Florida, April 28- May 1.
  • Huang SW, Tsai HP, Kuo PH, Wang JR. 2001. Genetic analysis of echovirus associated with outbreak of aseptic meningitis in Taiwan in 2001. The 35th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Dec. 16.
  • Tsai HP, Huang SW, Kuo PH, Wang JR. 2001. Echovirus 30 associated with outbreak of aseptic meningitis in Taiwan in 2001. The 2001 annual meeting of the Chinese Society of Medical Technology, Taipei, Taiwan, Oct. 21.
  • Wang JR, Tuan YC, Chen PF, Yu JS, Tsai HP, Kuo PH. 2001. Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and mouth disease in Taiwan between 1998 and 2000. The 17th Clinical Virology Symposium, Clearwater Beach, Florida, April 29-May 2. Abstract S43.
  • Tsai HP, Yan JJ, Wang JR. 2000. Comparison of primer sets for detection of enterovirus 71 from clinical specimens by RT-PCR. The 34th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Dec. 3.
  • Kuo PH, Tsai HP, Chen PF, Yu JS, Tuan YC, Wang JR. 2000. Analysis of enterovirus 71 isolated from 1998 to 2000. The 34th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Dec. 3.
  • Wang JR, Yan JJ, Chen PF, Tsai HP, Su IJ. 2000. Rapid identification of enterovirus 71 and coxsackievirus A16 by RT-PCR. The 16th Clinical Virology Symposium, Clearwater Beach, Florida, April 30-May 3. Abstract M26.
  • Chen PF, Yan JJ, Lai YR, Tsai HP, Su IJ, Wang JR. 1999. Rapid identification of enterovirus 71 and coxsackievirus A16 by RT-PCR. The 4th Chinese Laboratory Medicine Conference, Taipei, Taiwan, Oct. 22-24.
  • Wang JR, Tsai HP, Chen PF, Lai YJ, Su IJ. 1999. Laboratory diagnosis and genetic analysis of 1998 enterovirus 71 isolates in Taiwan. XIth International Congress of Virology, Sydney, Australia, Aug. 9-13.
  • Tsai HP, Lai YJ, Wang YF, Liu CC, Su IJ, Huang KY, Wang JR. 1998. Comparison on identification of enterovirus 71 and coxsakievirus A16. The 32th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Nov. 26-30. abstract V-3. CSM-87.

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