黃溫雅 教授 |
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Wen-Ya Huang |
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辦公室電話: | 5767 |
辦公室地點: | 醫技系三樓5766室 |
電子信箱: |
whuang@mail.ncku.edu.tw |
學術成大: |
黃 溫雅 |
Publons: |
Wen-Ya Huang |
1.肝癌發生(hepato-carcinogenesis)與B型肝炎病毒感染之關係與分子機轉: B型肝炎病毒感染是導致肝癌很重要的原因。在癌症發生過程中,細胞常發生基因不穩定性(genomic instability)。因此維持基因的穩定與完整性對於預防癌症發生扮演重要的角色。我們發現B型肝炎病毒的表面抗原pre-S2突變種會造成基因不穩定性及造成DNA損害(DNA damage)。因此我們以B型肝炎病毒為study model,探討慢性B型肝炎帶原者在轉變成肝癌的過程中DNA damage與DNA repair機制的調控及其對HCC發生的影響。
2.DNA Repair 之分子病理: DNA Repair (DNA修復)是細胞內維持DNA結構完整及修復DNA損害最重要的一個機制。當生物體DNA受到環境途變原(environmental mutagens)例如x-ray,紫外線,以及有毒化學物質等刺激而引起DNA結構不正常時,就需靠DNA Repair 功能來使之恢復正常功能。DNA Repair 功能異常的病人由於DNA突變率較高,導致癌症的機率較正常人高出許多。我們主要的研究方向為探討DNA Repair的分子機轉及其調控,尤其是近年來才分離出的因子hHR23 A及hHR23B (human homolog of Rad23 A / B),探討其在DNA Repair過程中所扮演的角色。除此之外,我們也利用微矩陣(Microarray)生物晶片技術來探討紫外線等環境途變原所引發的DNA Repair分子機轉。同時我們也進一步分析DNA Repair不正常病人的細胞株,以了解DNA Repair異常所引發的相關病理機制。
〔助理〕
姓名 | 研究主題 |
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李○萍 | Development of a serological detection method for hepatitis B virus large surface antigen. |
陳○玉 | Association of the oncofetal Nei endonuclease VIII-like 3 protein with hepatitis B virus-induced cirrhosis. |
〔博士後研究員〕
姓名 | 研究主題 |
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張○媖 | The interactive mechanism of hepatitis B virus surface protein and importinα1 and the effect of this complex for DNA damage in hepatocarcinogenesis. |
〔碩士班〕
姓名 | 論文題目 |
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艾○琳(醫技所二年級) | Development of hepatitis B virus large surface antigen pre-S2 mutant DNA and protein detection method in chronic carriers. |
林○酉(醫技所二年級) | Inhibition of integrin-mediated adhesion and migration of hepatoma cells by disintegrins. |
蘇○雅(醫技所一年級) |
〔已畢業博士〕
姓名 | 研究主題 |
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謝○璇(基醫所)-2007畢 | Genomics instability induced by HBV Pre-S mutant surface proteins |
〔已畢業碩士〕
姓名 | 論文題目 |
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賴○婷 (分醫所)-2002畢 | The protein interaction studies of the two human nucleotide excision repair factors hHR23A and hHR23B and their roles as protein degradation regulators |
蔡○和 (醫工所)-2002畢 | Application of cDNA microarray on studies of UVC-induced cell’s gene expressions |
謝○璇 (醫技所)-2003畢 | Oxidative stress and genomic instabilities caused by the HBV pre-S mutant surface antigens |
黃○忻 (分醫所) -2003畢 | Functional studies of the human hHR23A and hHR23B proteins in DNA repair and proteolysis |
謝○娟 (醫工所) -2004畢 | Functional studies of DNA repair genes hHR23A and hHR23B |
王○閔 (醫技所)-2005畢 | Genetic polymorphisms associated with breast cancer in south Taiwan |
蔡○霓 (醫技所)-2005畢 | Studies of antioxidant activities in Agaricus blazei Murill extracts |
王○婷 (分醫所)-2006畢 | Association of mitochondrial function with chemo-resistance in lung cancer cells |
許○斐 (醫技所)-2006畢 | Screening and functional studies of human proteins which interact with Streptococcal pyogenic exotoxin B (SPE B) |
董○蕙 (分醫所)-2007畢 | Screening and functional studies of human proteins which interact with DNA-damage binding protein (DDB2) |
黃○君 (醫技所)- 2007畢 | Functional studies of HBV surface antigen pre-S2 mutation with its association of JAB1 and KPNA2 |
李○陵 (醫技所)-2009畢 | Association of human 8-oxoguanine DNA glycosylase 1 isoform with NDUFB10 and its potential role in mitochondrial DNA repair |
蘇○虹(醫技所)-2010畢 | Functional studies of the α- and β-hydroxyguanine glycosylases in mitochondrial DNA repair |
阮玉○兒(醫技所)-2010畢 | Microsatellite instability caused by pre-S2 mutant LHBS |
劉○傑 (醫技所)-2010畢 | Genomic instability in hepatitis B virus-induced hepatoma in transgenic mice. |
高○齡 (醫技所)-2011畢 | Studies of the killing effects of HDAC inhibitor sulforaphane to hepatoma cell lines. |
李○萍 (醫技所)-2012畢 | Functional characterization of the human base excision repair factor nth endonuclease III-like 1. |
李○翰 (醫技所)-2012畢 | Development of a serological detection method for hepatitis B virus large surface antigen. |
陳○玉 (醫技所)-2013畢 | Association of the oncofetal Nei endonuclease VIII-like 3 protein with hepatitis B virus-induced cirrhosis. |