個人資料2018/04/04

陳怡伶助理教授
Yi-Lin Chen
辦公室地點：	成大醫院病理部分子診斷
電子信箱：	emerald@mail.ncku.edu.tw

開授課程

Molecular Diagnosis Technology/ Techniques in Molecular Diagnosis、Molecular diagnosis in HLA Typing
Clinical Cytogenetics and Molecular Genetics Rotations
Hematology /Molecular Diagnosis in Hematology
醫學生物技術概論/次世代定序在生物醫學的應用
實驗診斷概論/分子診斷
臨床生化實驗/ CYP2C9*1/*3

學歷

成大分子醫學碩士

經歷

國立成功大學醫技系(2014) 助理教授 Associate Professor, National Chen Kung University R.O.C
國立成功大學附設醫院病理部分子病理科醫檢師兼組長 (2010~迄今)
國立成功大學醫技系(2006) 講師 Instructor, National Chen Kung University R.O.C.
國立成功大學附設醫院病理部分子診斷醫檢師 (2004~迄今)
國立成功大學附設醫院病理部血庫醫檢師 (1990~2004)

實驗室研究方向

組織相容抗原與抗體分型
器官移植符合配對
白血病與淋巴癌之分子診斷
癌症基因相關研究
次世代基因定序: 菌相分析 (Metagenomics)及癌症基因組 (Cancer Panel)

指導學生

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指導學生之特殊榮譽

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榮譽及獎勵

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專利

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技術轉移

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期刊論文

2002~2017年

Chung-Ta Lee, Yu-Chuan Huang, Liang-Yi Hung, Nan-Haw Chow, Pei-Fang Su, Chung-Liang Ho, Hung-Wen Tsai, Yi-Lin Chen, Shao-Chieh Lin, Bo-Wen Lin, Peng-Chan Lin and Jenq-Chang Lee. Serrated adenocarcinoma morphology in colorectal mucinous adenocarcinoma is associated with improved patient survival. Oncotarget, 2017, Vol. 8, (No. 21), pp: 35165-35175
Chien-Wei Chen, Chin-Wei Kuo, Yi-Lin Chen, Chung-Liang Ho Wu-Chou Su, Chien-Chung Lin. Successful AZD9291 Therapy in Advanced Non–Small Cell Lung Cancer after Failure of HM61713. Journal of Thoracic Oncology 22 February 2017 June 2017Volume 12, Issue 6, Pages e72–e74
Wei-Lun Huang, Yi-Lin Chen(co-first author), Szu-Chun Yang, Chung-Liang Ho, Fang Wei, David T. Wong, Wu-Chou Su and Chien-Chung Lin.
Yi-Lin Chen, Chung-Ta Lee, Cheng-Chan Lu, Shu-Ching Yang, Wan-Li Chen, Yang-Cheng Lee, Chung-Hsien Yang, Shu-Ling Peng, Wu-Chou Su, Nan-Haw Chow, Chung-Liang Ho. Epidermal Growth Factor Receptor Mutation and Anaplastic Lymphoma Kinase Gene Fusion: Detection in Malignant Pleural Effusion by RNA or PNA Analysis. PLOS ONE | DOI:10.1371/journal.pone.0158125 June 28, 2016
Sheng-Jou Hung, Yi-Lin Chen, Chia-Hung Chu, Chuan-Chun Lee, Wan-Li Chen, Ya-Lan Lin, Ming-Ching Lin, Chung-Liang Ho and Tsunglin Liu. TRIg: a robust alignment pipeline for nonregular T-cell receptor and immunoglobulin sequences. BMC Bioinformatics (2016) 17:433
Yi-Lin Chen, Chuan-Chun Lee, Ya-Lan Lin, Kai-Min Yin, Chung-Liang Ho, Tsunglin Liu. Obtaining long 16S rDNA sequences using multiple primers and its application on dioxin-containing samples. BMC Bioinformatics 2015, 16 (Suppl 18): S13-24
Yi-Lin Chen、Cheng-Chan Lu、Shu-Ching Yang、Ya-Lan Lin、Wan-Li Chen、Wenya Huang Nan-Haw Chow、Chung-Liang Ho. Verification of Wild-Type EGFR Status in NoneSmall Cell Lung Carcinomas Using a Mutant-Enriched PCR on Selected Cases. J Mol Diagn 2014 16: 486-494.
Po-Chang Lee, Yi Lin Chen, Wei-Ming Wang, Wan Chi Tu, and Hsuan Yu Chen. Clinical Relevance of Pre- and Post-Transplant HLA Antibodies, Donor-Specific, and Non- Donor-Specific HLA Antibodies Detected by ELISA in Renal Transplantation. Clinical Transpl. 2013:385-91. PMID: 25095533
陳怡伶, 周楠華, 呂政展, 黃溫雅, 何中良. 分子診斷實驗室之規劃 The Design of Molecular Diagnostic Clinical Laboratory J Biomed Lab Sci, 2013: 25(2): 45-55
陳怡伶,尹開民,林雅嵐,李權君,劉宗霖,顏經洲,何中良.焦磷酸定序應用於戴奧辛污染土壤微生物菌群分析.環境分析評論第七期
陳怡伶, 尹開民,周怡旻. Pyrosequencing.環境分析評論第六期
Meng-Fang Li, Cheng-Hsiang Hsiao, Yi-Lin Chen, Wen-Ya Huang, Yi-Hsuan Lee, Hsien-Neng Huang and Huang-Chun Lien. Human herpesvirus 8-associated lymphoma mimicking cutaneous anaplastic large T-cell lymphoma in a patient with human immunodeficiency virus infection. J Cutan Pathol. 2012 Feb;39(2):274-8
Chen YL, Su IJ, Cheng HY, Chang KC, Lu CC, Chow NH, Ho CL, Huang W. BIOMED-2 protocols to detect clonal immunoglobulin and T-cell receptor gene rearrangements in B- and T-cell lymphomas in southern Taiwan. Leuk Lymphoma 2010 April; 51(4):650-655
Yu-Min Yeh, Chen YL(co-first author), Hsieh-Yin Cheng, Wu-Chou Su, Nan-Haw Chow, Tsai-Yun Chen, Chung-Liang Ho.High Percentage of JAK2 Exon 12 Mutation in Asian Patients. American Journal of Clinical Pathology 2010:134: 266-270
Tan CY, Chen YL, Wu LS, Liu CF, Chang WT, Wang JY. Association of CD14 promoter polymorphisms and soluble CD14 levels in mite allergen sensitization of children in Taiwan. J hum genet. 2006 51(1):59-67. Epub 2005 Nov 15.
Chen YL, Chen JC, Lin TM, Huang TJ, Wang ST, Lee MF, Wang JY. ABO/secretor genetic complex is associated with the susceptibility of childhood asthma in Taiwan Clin Exp Allergy. 2005 Jul;35(7):926-32.
RHD 1227A is an important genetic marker for RhD(el) individuals. Chen JC, Lin TM, Chen YL, Wang YH, Jin YT, Yue CT. Am J Clin Pathol. Aug;122(2):193-8. 2004
All chronic rejection failures of kidney transplants were preceded by the development of HLA antibodies. Lee PC, Terasaki PI, Takemoto SK, Lee PH, Hung CJ, Chen YL, Tsai A, Lei HY Transplantation 27;74(8):1192-4. 2002

研討會論文

2010~2017年

Yi-Lin Chen, Chung-Ta Lee, Cheng-Chan Lu, Shu-Ching Yang, Wan-Li Chen, Yang-Cheng Lee, Chung-Hsien Yang, Shu-Ling Peng, Wu-Chou Su, Nan-Haw Chow, Chung-Liang Ho. Epidermal Growth Factor Receptor Mutation and Anaplastic Lymphoma Kinase Gene Fusion: Detection in Malignant Pleural Effusion by RNA or PNA Analysis. 2017醫檢年會(2017亞培優秀論文獎)
陳怡伶、林雅嵐、林旻靜、劉宗霖、黃溫雅、何中良.利用次世代基因定序分析台灣地區T細胞淋巴瘤個體之T細胞受體基因組合. 2013年第六屆亞太醫學檢驗科學國際研討會.(2013優秀口頭論文獎)
林雅嵐、陳怡伶、李權君、劉宗霖、何中良、顏經洲.次世代定序技術分析微生物菌群. 2013年第六屆亞太醫學檢驗科學國際研討會.(2013優秀口頭論文獎)
陳菀莉、陳怡伶、張孔昭、何中良、顏經洲.建立EML4-ALK檢測技術於肺癌病患之經驗分享.2013年第六屆亞太醫學檢驗科學國際研討會
林旻靜、陳怡伶、林雅嵐、陳菀莉、何中良.以FISH方法評估非小細胞腺癌之ALK轉位. 2013年醫檢年會
李權君、陳怡伶、林雅嵐、何中良、劉宗霖.Increasing the lengths of 16S rDNA sequences for accurate identification of bacterial species in dioxin containing samples. 2013年ISEGB
Yi-Lin Chen (陳怡伶), Wen-Ya Huang（黃溫雅）, Chung-Liang Ho (何中良), Wu-Chou Su (蘇五洲), Cheng-Chan Lu (呂政展). EGFR Mutation Analysis in Non-Small Cell Lung Cancers (NSCLC): Experience from a southern Taiwan molecular diagnosis core center (2011, Associated Molecular Pathology AMP annual meeting)
Yi-Lin Chen (陳怡伶), Yu-Min Yeh (葉裕民), Tsai-Yun Chen(陳彩雲), Chung-Liang Ho(何中良).High Percentage of JAK2 Exon 12 Mutation in Asian Patients with Polycythemia Vera (2010, Associated Molecular Pathology AMP annual meeting)

專書

Po-Chang Lee, Yi Lin Chen, Wei-Ming Wang, Wan Chi Tu, and Hsuan Yu Chen. Clinical Relevance of Pre- and Post-Transplant HLA Antibodies, Donor-Specific, and Non- Donor-Specific HLA Antibodies Detected by ELISA in Renal Transplantation. Clinical Transplants 2013. Chapter 46: P385-391 Los Angles, Terasaki Foundation Laboratory.

醫學分子檢驗: 藥物基因體學之分子診斷。黃溫雅，陳怡伶。(2017)

醫學檢驗品質管制: 醫學分子檢驗實驗室之品質管制章節。黃溫雅，陳怡伶，楊淑清，林旻靜，陳菀莉。(2014)

行政院環境保護署環境檢驗所101年度委託計畫(EPA-101-1502-02-01): 新世代高通量焦磷酸定序技術開發期末報告。

Chinese handbook of kidney transplantation (Second Edition). Chapter 2

Genetics Evidence that polymorphisms of TNFα promoter and HLA-DR, -DQ genes within chromosome 6p21 are associated with childhood asthma in Taiwanese. Chen YL, Wang JY., Lu CC. 2001.

作品發表(含展演)

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Other publications

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研究計畫

院內計劃: 每年約一件

主辦、參與國際會議

	時間(迄)	地點	主辦單位	主題
106.12.06	106.12.10	Japan	Molecular Biology Society of Japan	2017 Consortium of Biology Science
104.07.16	104.07.19	Japan	JSMO	Molecular Pathology
103.3.14	103.0316	Hong Kong	ICAMT	Molecular Pathology
101.07.11	101.07.13	Hong Kong	Hong Kong Society for Histocompatibility and Immunologentics	2012 HLA相關研討會
101.02.13	101.02.15	上海亞太定序技術中心	參加亞太定序技術中心訓練，獲得相關教育訓練證書	次世代定序技術及軟體分析訓練
100.11.15	1001119	Grapevine, Texas	American Molecular Pathology (AMP)	AMP 2011 annual meeting
99.11.16	991120	San Jose McEnery Convention Center	American Molecular Pathology (AMP)	AMP 2010 annual meeting
96.10.27	961031	加拿大	ASHI (American Society for histocompatibility and immunogenetics)	2008 ASHI Annual Meeting
92.04.16	920417	World Trade Center Club, Taipei, Taiwan	One Lambda, Inc	1. The Clinical Significance of HLA Antibodies in Transplantation 2. Antibody Screening and Monitoring Technologies 3. Flow Cytometry-Luminex Multiplex Beads 4. Bone Marrow Transplantation 5. Basic HLA
84.12.09	841210	台北醫學院	國科會生命科學推動中心	分子生物技術研習會
83.08.29	830929	馬偕紀念醫院		醫事檢驗科血庫代訓

教學、研究國際交流

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