Education

1993 Microbiology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, USA
1991 Microbiology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, USA
1983 Medical Technology, Taipei Medical College, Taipei, Taiwan

Research

Research interests of Prof. Jen-Ren Wang

Viral pathogenesis, virus-host cell interaction, diagnostic virology, enterovirus 71, epidemiology of enteroviruses and influenza viruses, virulence gene analysis of enterovirus 71 and influenza viruses.

My research focuses on clinical diagnostic virology, viral surveillance, molecular epidemiology of re-emergent virus, analysis of virulence gene and pathogenesis of enterovirus and influenza virus

1. Clinical Virology
1.1 Echovirus 30 (Wang et al, J Clin Microbiol 40: 4439-4444, 2002)

For clinical diagnostic virology, we have collaborated with the physicians at the National Cheng Kung University Medical Center, the regional hospitals, and primary care clinics to establish virus watch program in southern Taiwan. For example, we found a large outbreak of aseptic meningitis occurred from April to November in Taiwan in 2001. Of the 1,130 enterovirus-infected patients, echovirus 30 (E30) infection was diagnosed in 188 (16.6%). The virus isolates were initially identified as echovirus 4 (E4) on the basis of immunofluorescence staining with anti-E4 and anti-E30 (Bastianni prototype) monoclonal antibodies. However, upon performance of the neutralization test, E30-specific reverse transcription-PCR, and sequencing of the VP1 gene, the results identified these isolates as E30, not E4. The findings indicate that the reagent used to type E30, which is produced with the Bastianni strain as the immunogen, is inadequate for the identification of recent E30 isolates in Taiwan. Phylogenetic analyses of the VP1 genes of these isolates showed that their sequences differed from those of E30 isolates from the GenBank database, suggesting that this outbreak was caused by a new variant strain of E30 introduced into Taiwan in 2000 that resulted in the widespread aseptic meningitis epidemic in 2001.

1.2 Echovirus 18 (Tasi et al, J Med Microbiol 60(9):1360-1365, 2011. figure on cover)

An outbreak of aseptic meningitis occurred in Taiwan from April to August 2006. We found that major isolates from the 2006 outbreak of aseptic meningitis in Taiwan were echovirus 18 (27.4%, 93 cases) and the case fatality rate among children was 4%. Phylogenetic analyses of the partial VP1 gene showed there is 3.7-23.8% variation in their sequences compared from the GenBank database, and two notable position changes were substitution in V152S or V152Q and deletion in Q158. These mutations resulted in an antigenic drift in the loop of VP 1 protein in three-dimensional structure. In conclusion, a new variant E18 was circulating and caused an outbreak of aseptic meningitis.

2. Enterovirus 71 (Huang, et al. J Clin Microbiol. 2009. 47(11):3653-62.)

In recent years, enterovirus 71 (EV71) has been a cause of numerous outbreaks of hand-foot-and-mouth disease, with severe neurological complications in the Asia-Pacific region. We found that the reemergence of EV71 genotype B5 in 2008 resulted in the largest outbreak of EV71 in Taiwan in the past years. Phylogenetic analyses indicated that dominant genotype changes from B to C or C to B occurred at least three times between 1986 and 2008. Furthermore, antigenic cartography of EV71 by using neutralization tests revealed that the reemerging EV71 genotype B5 strains formed a separate cluster which was antigenically distinct from the B4 and C genotypes. Moreover, analyses of full-length genomic sequences of EV71 circulating in Taiwan during this period showed the occurrence of intra- and interserotypic recombination. Therefore, continuous surveillance of EV71 including the monitoring of genetic evolution and antigenic changes is recommended and may contribute to the development of a vaccine for EV71.

3. Pathogenesis of enterovirus 71
3.1 Introduction of a strong temperature-sensitive phenotype into enterovirus 71 by altering an amino acid of virus 3D polymerase (Kung, et al. Virology. 2010. 396:1-9.)

In 1998, an enterovirus 71 (EV71) epidemic in Taiwan resulted in 78 deaths; however, the molecular basis ofEV71 pathogenicity remains poorly understood. Comparison of the deduced amino acid sequences in 3Dpolymerases of EV71clinical isolates showed the T251V or T251I substitution from 1986 to 1998 outbreaks. An EV71 replicon system showed that introducing an I251T mutation did not affect luciferase activities at35 °C when compared with wild type; however, lower luciferase activities were observed when they were incubated at 39.5 °C. In addition, the I251T mutation in the EV71 infectious clone not only reduced viral replication at 39.5 °C in vitro but also decreased the virulence of the mouse adaptive strain MP4 in neonatal mice in an i.p. infection model. Therefore, these results suggested that the threonine at position 251 results in a temperature sensitivity phenotype of EV71 which may contribute to the attenuation of circulating strains in 1986.

3.2 A single nucleotide in stem loop II of 5'-untranslated region contributes to virulence of enterovirus 71 in mice (Yeh, et al. Plos One. 2011. 6(11): e27082.)

In this report, we investigated increased virulence of unadapted EV71 clinical isolate 237 as compared with isolate 4643 in mice. A fragment 12 nucleotides in length in stem loop (SL) II of 237 5'-untranslated region (UTR) visibly reduced survival time and rate in mice was identified by constructing a series of infectious clones harboring chimeric 5'-UTR. In cells transfected with bicistronic plasmids, and replicon RNAs, the 12-nt fragment of isolate 237 enhanced translational activities and accelerated replication of subgenomic EV71. Finally, single nucleotide change from cytosine to uridine at base 158 in this short fragment of 5'-UTR was proven to reduce viral translation and EV71 virulence in mice. Results collectively indicated a pivotal role of novel virulence determinant C158 on virus translation in vitro and EV71 virulence in vivo. These results presented the first reported virulence determinant in EV71 5'-UTR and first position discovered from unadapted isolates.

3.3 Mutations in VP2 and VP1 capsid proteins increase cytotoxicity and mouse lethality of enterovirus 71 via virus binding and RNA accumulation enhancement. (Huang, et al. Virology. 2012. 422:132-143)

EV71 infection occasionally associates with severe neurological sequelae such as brainstem encephalitis or poliovirus-like paralysis, but cytotoxicity and mouse lethality determinants remain unclear. We demonstrated how mouse-adapted virulent strain can induce more apoptosis of neuron cells and proved more virulent for neonatal mice than the non-virulent strain. Results pointed to EV71capsid region determining viral cytotoxicity, virus growth, and mouse lethality. In addition, mutant virus with lysine to methionine substitution at VP2149 (VP2149M) or glutamine to glutamic acid substitution at VP1145 (VP1145E) showed increased apoptosis and viral titers in Neuro-2a cells. Synergistic effect of VP2149M and VP1145E double mutations enhanced viral binding and RNA accumulation in infected Neuro-2a cells. These dual substitution mutants significantly reduced value of 50% lethal dose in neonatal mice infection, indicating they raised mouse lethality in vivo. In sum, VP2149Mand VP1145E mutations cooperatively promote viral binding and RNA accumulation of EV71, contributing to cytotoxicity and viral production in vitro and mouse lethality in vivo.

3.4 EV71 work accomplished and studies in progress by the PI:

We continued to investigate the genetic evolution of EV71 for more than a decade long. We collaborated with Dr. Derek Smith from the University of Cambridge and established the first antigenic map of EV71. This cartography provided an all new sight for antigenic property change of EV71. In addition, we determined the viral genome recombination and performed a dynamic genetic evolution study of EV71. In the past of our studies, we primarily focused on molecular epidemiology, virulence determinants and pathogenesis of EV71. Through these studies, we have established various platforms, including in vitro culture in various cell lines, EV71 replicons, infectious clones, and in vivo animal model.

4. Influenza virus
4.1 Genetic analysis of influenza virus (Tasi et al J Clin Microbiol 44: 2705-2713, 2006)

As another re-emergent virus, we also have analyzed the genetic and antigenic evolution of influenza B virus field strains isolated in Taiwan from 1998 to 2005. All influenza B viruses isolated between 1998 and 2000 belonged to the B/Yamagata/16/88 lineage. The B/Victoria/2/87 lineage, which was cocirculated with the Yamagata lineage, was identified in Taiwan in March 2001. Since 2002, genetic reassortants of influenza B virus with the Victoria lineage of hemagglutinin and the Yamagata lineage of neuraminidase have been found at a rate of 46%. Therefore, in 2002, at least three sublineages of influenza B virus strains, the B/Shanghai/361/2002-like strain (Yamagata lineage), the B/Hong Kong/330/01-like strain (Victoria lineage), and the B/Hong Kong/1351/02-like strain (B reassortant lineage), were identified in Taiwan. The results showed that genetically distinct lineages can cocirculate in the population and that the reassortment among these strains plays a role in generating the genetic diversity of influenza B viruses. Interestingly, from January to April 2005, B reassortant viruses became dominant (73%) in Taiwan, which indicated that a mismatch had occurred between the influenza B vaccine strain recommended for the 2004-2005 season in the Northern hemisphere by the World Health Organization and the epidemic strain.

4.2 Humoral response against 2009 pH1N1 (Chi et al. Clin Vaccine Immunol 17(12):1958-1962, 2010.)

Due to the important role of the antibody-mediated immunity in the protection of influenza infection, we investigated the cross-reactive neutralizing antibodies against 2009 pH1N1 of 229 stored sera from donors born between 1917 and 2008 in Taiwan using enzyme-linked immunosorbent assay-based microneutralization test. The peak of cumulative geometric mean titer was in donors aged over 90 years and declined sharply afterward. Sixteen of 27 subjects (59%) aged over 80 years had cross-reactive antibody titer of 160 or more against the 2009 pH1N1, whereas none of the donors from age 9 to 49 had an antibody titer of 160 or more. Interestingly, 2 of 51 children (4%) ranging in 6 months to 9 years old had an antibody titer of 40. We further tested the antibody response in 9 of the 51 pediatric sera to three endemic seasonal influenza viruses isolated in 2006 and 2008 in Taiwan, and the results showed only the 2 sera from children with antibody responses to 2009 pH1N1 had high neutralizing antibody titer against recent seasonal influenza strains. Our study shows the presence of some level of cross-reactive antibody in Taiwanese persons 50 years or older, and the elderly subjects who may already be exposed to the 1918 virus had high neutralizing antibody titer to the 2009 pH1N1. Our data also indicate that natural infection with the Taiwan 2006 and 2008 seasonal H1N1 viruses may induce cross-reactive antibody response to 2009 pH1N1.

Currently, the EV71 and influenza virus investigations at National Cheng Kung University have been organized into two study groups. Many PIs were involved in these groups, including infectious disease specialists, pediatricians, epidemiologist, immunologists, virologists, and pathologists.

Professional Experience

2002-present Professor - Dept. of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
1999 - present Principal investigator, Department of Health, Taiwan Centers for Disease Control Virology contract Laboratory, National Cheng Kung University Medical Center (NCKUMC)
1998 - present Principal investigator, National Health Research Institutes (NHRI) Tainan Virology Laboratory for Diagnosis and Research, NCKUMC
2010-2013 Chairperson - Dept./Institute of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
1994 - 2002 Associate professor - Dept. of Medical Technology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
1994 - present Establish and in charge Virology Laboratory at National Cheng Kung University Medical Center
1993 - 1994 Research Instructor - Department of Microbiology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo (SUNY), Buffalo, NY, U. S. A.
1992 - 1994 Postdoctoral Fellow - Postdoctoral Training Program in Medical and Public Health Laboratory Microbiology, Division of Clinical Microbiology & Immunology, Erie County Medical Center, SUNY at Buffalo, Buffalo, NY, U. S. A.
1991Teaching Assistant - Department of Microbiology, School of Medicine and Biomedical Sciences, SUNY at Buffalo, Buffalo, NY, U. S. A.
1988-1992 Research Assistant of Dr. Murray W. Stinson, Department of Microbiology, School of Medicine and Biomedical Sciences, SUNY at Buffalo, Buffalo, NY 14214. Project title: Pathogenic mechanism of Streptococcus pyogenes.
1987.1988Research Assistant of Dr. Emanuel Goldman, Department of Microbiology, Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Newark, NJ, U. S. A.
1983-1987 Medical Technologist - Cathay General Hospital, Taipei, Taiwan.

Honors and awards

1987-1988 Graduate Fellowship, University of Medicine and Dentistry of New Jersey
1988-1993 Graduate Fellowship, State University of New York at Buffalo
1992 Erwin Necter award (Western New York Branch, American Society for Microbiology)
1996-present Committee member, Taiwan Medical Technologist Licensing Examination Committee
1998 Ten Outstanding Young Woman Award in Taiwan (Golden Phoenix Award 17th)
2002-present Invited member, Asia-Pacific Advisory Committee on Influenza
2004, 2006 Ph. D. External Examiner in Microbiology, Chinese University of Hong Kong
2007 Invited member, Asia-Pacific Pediatric Influenza Vaccination Advisory Board
2008-present Advisory committee member, Clinical Virology Specialist Committee, Taiwan
2010-present Councilor, Taiwan Society for Microbiology
2015-present Associate Editor for the Journal of Medical Virology
2016 Editorial Board member for the Journal of Virology Methods
2016 External Assessor for promotion for University of Malaya

Other activities

Organizing committee and speaker, International workshop on diagnosis of viral and chlamydial infection. Presentation entitled “Laboratory diagnosis of viral infections”, April 6-10, 1994.
Organizing committee and speaker, Second international symposium on diagnosis of viral and chlamydial infections. Presentation entitled “Laboratory diagnosis of cytomegalovirus infections”, March 31-April 2, 1996.
Organizing committee and speaker, Symposium on clinical virology and bacteriology. Presentation entitled “Experience in operation of clinical virology laboratory”, March 15-16, 1997.
Invited speaker and participant, Department of Health Meeting to discuss the control and prevention of enterovirus 71 infections, June 26, July 4, July 22, 1998.
Invited speaker, presentation entitled “Respiratory viral infections and influenza H5N1”, Symposium on Clinical Microbiology, July 11, 1998.
Invited speaker, presentation entitled “Laboratory diagnosis of viral infection in Obs/Gyn clinics”, Symposium on New Horizon in Obs/Gyn, July 26, 1998.
Invited speaker, presentation entitled “Enterovirus 71 infections”, Bureau of Commodity Inspection & Quarantine, Ministry of Economic Affairs, Aug. 11, 1998.
Invited speaker and participant, Department of Health Meeting to discuss the control and prevention of enterovirus 71 infections in southern Taiwan, Oct. 7, 1998.
Invited speaker, Symposium on the control and prevention of infectious diseases, Department of Health, Nov. 23-24, 1998.
Invited participant, Department of Health meeting to discuss the control and prevention of influenza virus H5N1 infections, Dec. 23, 1998.
Invited speaker, “Enterovirus infections and pregnancy”, Symposium on New Horizon in Obs/Gyn, Jan. 17, 1999.
Organizing committee and speaker, Third international symposium on diagnosis of viral and chlamydial infections. Presentation entitled “ Laboratory diagnosis and genetic analysis of enterovirus 71”, March 12-13, 1999.
Invited speaker, Symposium on control and prevention of enterovirus infections, May 20, 1999.
Invited speaker, “Enterovirus 71 epidemic in Taiwan-clinical manifestations, epidemiology, laboratory diagnosis and genetic analysis”, The Korean Society of Clinical Pathologists, The 4th Honam and Youngnam Joint Conference, Korea, June 19, 1999.
Invited speaker, presentation entitled “Laboratory diagnosis and molecular epidemiology of 1998 enterovirus 71 isolates in Taiwan”, Symposium: advanced in clinical virology, Taipei VA Medical Center, Oct. 25-26, 1999.
Invited panelist, APEC symposium: enteroviral watch program for children-enterovirus 71 epidemic in Asia Pacific Area, Center for Disease Control, Department of Health, Taipei International Convention Center, Chinese Taipei, March 26-27, 2000
Invited speaker, presentation entitled “Enterovirus 71 epidemic: laboratory diagnosis and molecular epidemiology”, Symposium: advances in biotechnology and medical technology, Taipei Medical College, May 13, 2000.
Invited speaker, presentation entitled “Influenza virus activity in southern Taiwan from 1997 to 2000”, Symposium on influenza virus and H. pylori, Chinese Society of Microbiology, December 3, 2000.
Invited speaker, presentation entitled “Enterovirus 71 epidemics in Taiwan”, Symposium on enterovirus 71 and hantavirus, Taiwan Center for Disease Control/Department of Health, March 3 and 24, 2001.
Invited speaker, presentation entitled “Diagnostic and molecular virology of enterovirus 71”, The 9th SCBA International Symposium. Society of Chinese Bioscientists in America, Aug. 6-10, 2001.
Invited speaker, presentation entitled “Foot-and-mouth disease and enterovirus”, 2001 annual meeting of the Society of Medicine, Taipei, Nov. 11, 2001.
Invited speaker, presentation entitled “Enterovirus outbreaks between 1998 and 2001”, Symposium on new advances in virology and parasitology, Dec. 9, 2001.
Invited speaker, presentation entitled “C. trachomatis- and N. gonorrhoeae- infections detected by ligase chain reaction (LCR) of cervical swabs and urine in women attending STD or gynecology clinics in Taiwan”, Symposium on STD. Taiwan Center for Disease Control/Department of Health, March 17, 2002.
Invited speaker, presentation entitled “Molecular analysis of enterovirus outbreaks between 1998 and 2001”, New Initiatives in Old Clinical Problems in Taiwan. NHRI, April 13, 2002.
Invited member, Asia Pacific Advisory Committee on Influenza, presentation entitled “Influenza activity in Taiwan”, June 9, 2002.
Invited speaker, presentation entitled “Molecular analyses of enterovirus outbreaks in Southern Taiwan”, Current status & challenge of infectious diseases in Asia. NHRI/NCKU, Feb. 21-22, 2003.
Invited speaker, presentation entitled “The Role of Sentinel Physician in Influenza epidemics”. “Symposium on Influenza and SARS Epidemics” Aug, 23, 2003.
Invited speaker, presentation entitled “Laboratory Diagnosis of viral pneumonia”. Chinese Society for Microbiology. Nov, 29-30, 2003.
Invited speaker, presentation entitled “Analysis of Recent Enterovirus Outbreaks in Taiwan” “2004 Symposium on Enterovirus Prevention and Control” April. 9, 2004.
Invited speaker, presentation entitled “Viral Activity is Southern Taiwan”, Chinese Society for Infectious Disease-Case Conference in Tainan. April. 17, 2004.
Invited speaker, presentation entitled“Role of sentinel surveillance in influenza outbreak”2004 Asia Pacific Intercity Symposium on Influenza Control and Prevention. May 22, 2004.
Invited speaker, presentation entitled“Molecular diagnosis of enterovirus epidemic in Taiwan”, Symposium on the latest advancement in molecular diagnostic microbiology. American-Chinese Society for Microbiology. Sep. 15-16, 2004.
Invited speaker, presentation entitled“Avian influenza and recent change of influenza Taiwan”2005 Symposium for Continuing Education of Medical Technologist. March 25, 2005.
Invited speaker, presentation entitled “Laboratory Diagnosis of Enterovirus” Clinical Diagnosis and Management of Severe Enterovirus Infection. March 27, 2005.
Invited speaker, presentation entitled“Surveillance and Laboratory Diagnosis of Influenza and Enterovirus Epidemics” 2005 Continuing Education for Sentinel Physicians. May 1, 2005.
Invited speaker, presentation entitled “Enterovirus 71 and its pathogenicity” Pasture/NHRI/CDC Symposium on Re-emerging Virus Infections, Taiwan, Sep. 1-3, 2006.
Invited speaker, presentation entitled“Genetic analysis of enterovirus 71-from clinical virology to basic research” Symposium on Natural Products and Microbiology. Chia-Yi University. Oct. 26, 2007.
Invited speaker, presentation entitled “Influenza A H5N1. The Genetic Evolution of H5N1. The 100th Annual Meeting of the Society of Medicine, Taipei, Nov. 9-11, 2007.
Invited speaker, presentation entitled “Current influenza vaccine use in Taiwan”, Asia-Pacific Pediatric Influenza Vaccination Advisory Board meeting. Bangkok, Thailand. Nov. 18, 2007.
Invited speaker, presentation entitled “Returning of EV71: epidemiology and genetic analysis”. Taiwan-Singapore Minisymposium on Reemerging of Enterovirus 71. Tainan, July 23, 2008.
Invited speaker, presentation entitled “Current status of Enterovirus 71”. Symposium on Enterovirus 71 Prevention & Control. 2008 Annual Meeting of the Taiwan Public Health Association. Taipei, Oct. 4-5, 2008.
Invited speaker, presentation entitled “Understanding and researching the enterovirus 71 and its pathogenicity for better prevention”, Pandemic Influenza and Enterovirus Preparedness & Control. Hong Kong, Sep. 18-19, 2008.
Invited speaker, presentation entitled “Human and avian influenza viruses”. Symposium on Influenza Preparedness & Control. 2008 Annual Meeting of the Taiwan Society of Internal Medicine. Taipei, Nov. 29, 2008.
Invited speaker, presentation entitled “Genetic and antigenic analyses of enterovirus 71”. 8th Asia Pacific Congress of Medical Virology. Hong Kong SAR, China. Feb. 25-28, 2009.
Invited speaker, presentation entitled “Genetic and antigenic analyses of enterovirus 71”. 2009 Taiwan-Swiss Biomedical Symposium. June 9-11, 2009.
Invited speaker, presentation entitled “The virology of seasonal influenza and 2009 pandemic influenza A (H1N1)”. Seminars on Seasonal Influenza and Pandemic Influenza H1N1. 2009 Annual Meeting of the Taiwan Society of Internal Medicine. Taipei, Nov. 8, 2009.
Invited speaker, presentation entitled “Molecular epidemiology and genetic analysis of enterovirus 71”. Indo-Taiwanese workshop on Infectious Diseases. Indian Institute of Science, Bangalore, India. Nov. 27-28, 2009.
Invited speaker, presentation entitled “Enterovirus 71 outbreaks from 1998 to 2009-unravel 1998 EV71 epidemic”. The 18th Annual Meeting of The Chinese Society of Cell and Molecular Biology. Kenting, Taiwan. Jan. 20-22, 2010.
Invited speaker, presentation entitled “Lessons from enterovirus 71 epidemics: evolution of reemerging viruses and its impact”. The 2nd International Symposium “Vaccine from Research to Product Launch”. Miaoli, Taiwan. Oct. 7-8, 2010.
Invited speaker, presentation entitled “Mutations in VP2 and VP1 capsid proteins increase cytotoxity and mouse lethality of enterovirus 71”. Symposium on Receptor, Immunopathogenesis, and Therapy of Enterovirus 71 Infection. Tainan, Taiwan. Oct. 9, 2010.
Invited speaker, presentation entitled “Lessons from enterovirus 71 epidemics: evolution of reemerging viruses and its impact’. The 13th SCBA International Conference in Guangzhou, China. July 25-29, 2011.
Invited speaker, presentation entitled “Antigenic evolution of EV71 and impact on vaccine development”. The 1st International Symposium of Vaccine Development against Human Hand-Foot-and-Mouth Diseases. Zhunan, Taiwan. Sep. 4-5, 2011.
Invited speaker, presentation entitled “Genetic analysis of enterovirus 71 and its impact on pathogenesis”. 2011 International Symposium on Infectious Disease and Signal Transduction. Tainan. Nov. 19-20, 2011.
Invited speaker, presentation entitled “Genetic and antigenic analyses of enterovirus 71 and their implications”. 2011 First Cross Strait Symposium on Development of Drug and Biomedical Products. 2011年第一屆兩岸醫藥品研發合作研討會. Taipei. Dec. 13-14, 2011.
Invited speaker, presentation entitled “Laboratory surveillance of Influenza and respiratory infections in flu season”. Conference on Continuing Threat of Influenza: Epidemiology, Transmission, Management, and Control Policy. Taipei. Sep. 1, 2012.
Invited speaker, presentation entitled “Returning of EV71: epidemiology and genetic analysis”. International Minisymposium on Reemerging of Enterovirus 71-Southeast Asia and Taiwan Universities (SATU) Joint Research Scheme on EV71, Tainan, Taiwan, Sep. 13.
Invited speaker, presentation entitled “Impact of genetic variations of enterovirus 71 on antigenicity and virulence”. 2012 International Symposium on RNA Viruses (Virus-Host Interactions), Taoyuan, Taiwan, Nov. 9-10.
Invited speaker, presentation entitled “Genetic, antigenic and serology analyses of human influenza viruses in southern Taiwan”. International Conference on Influenza Research. Tokyo Metropolitan Institute of Medical Science, Feb. 15, 2013.
Invited speaker, presentation entitled “Impact of enterovirus 71 evolution on antigenicity and virulence”. Symposium on Enterovirus 71. Chulalongkorn University, Thailand. Feb. 28, 2013.
Invited speaker, presentation entitled “Impact of genetic variations of enterovirus 71 on antigenicity and virulence”. ASEAN HFMD Scientific Workshop 2013 in Biopolis, Singapore, April 11-12, 2013.
Invited speaker, presentation entitled “EV71 vaccine development in NHRI Taiwan”. ASEAN HFMD Scientific Workshop 2013 in Biopolis, Singapore, April 11-12.
Invited speaker, presentation entitled “Highlights on 2013 Clinical Virology Symposium”. 2013 Clinical Virology Symposium on Diagnosis and Research. Chang Gung University Hospital. June 15, 2013.
Invited speaker, presentation entitled “Impact of enterovirus 71 evolution on antigenicity and virulence”. Symposium on New Development in Clinical Microbiology and Virology. Department of Health, Tainan City Government. June 18, 2013.
Invited speaker, presentation entitled “Avian influenza and influenza A (H7N9) virus”. Symposium on New Development in Clinical Microbiology and Virology. Department of Health, Tainan City Government. June 18, 2013.
Invited speaker, presentation entitled “Encountering emerging and reemerging viral infections in the past 20 years at NCKU”. Symposium for 42th-year Anniversary of Institute of Preventive Medicine, National Defense Medical Center. 國防醫學院預防醫學研究所42週年所慶暨學術研討會, March 3, 2014.
Invited speaker, presentation entitled “Genetic evolution of enterovirus 71 and its impact on virulence and antigenicity”. The Tenth Across the Taiwan Strait Symposium on Cell Biology, Penghu, April 21-25, 2014.
Invited speaker, presentation entitled “Genetic evolution of enterovirus 71 and its impact on virulence and antigenicity”. Taiwan CDC,May 12, 2014.
Invited speaker, presentation entitled “Encountering emerging and reemerging viral infections in the past 20 years at NCKU”. Tzu Chi University. May 26, 2014.
Invited speaker, presentation entitled “Lessons from enterovirus 71 epidemics: evolution of reemerging viruses and its impact”. 2014 International Symposium on Infectious Disease and Signal Transduction. Tainan. Nov. 2, 2014.
Invited speaker, presentation entitled “Evolutionary impact of enterovirus 71 on the pathogenicity and antigenicity”. Minisymposium at UCSF. Nov. 4, 2014.
Invited speaker, presentation entitled “Crossing species barrier of novel influenza virus from viral evolution”. Mini-symposium on Influenza and Emerging Pathogens. Dec. 6, 2014.
Invited speaker, presentation entitled “Continuing Changes of Human Influenza Viruses”. 台灣醫學會104年春季學術演講會. Tainan, Taiwan, May 23, 2015.
Invited speaker, presentation entitled “Dynamics of enterovirus 71 evolution: from global to the host”. The 15th SCBA (Society of Chinese Bioscientists in America) International Symposium. Taipei, Taiwan, June 28, 2015.
Invited speaker, presentation entitled “Dynamics of enterovirus 71 evolution: from global to the host”. International Symposium on Dengue virus, Enterovirus 71 and Tumor-Associated Viruses. Tainan, Taiwan, June 30, 2015.
Invited speaker, presentation entitled “Impact of enterovirus 71 evolution on virulence and antigenicity”. 10th Asia-Pacific Congress of Medical Virology 2015 (APCMV 2015). Taipei, Taiwan, Oct. 16, 2015.
Invited speaker, presentation entitled “Good microbiological laboratory practice and techniques” 2016 Biosafety Officer Training Workshop. 生物安全官教育訓練研習會. May 13.
Invited speaker, presentation entitled “Genome plasticity of enterovirus A71 affects antigenicity, viral fitness and pathogenicity. Hand, Foot and Mouth Disease International Conference, July25-26, Biopolis, Singapore.

Author

Wang JR. 1996. Chapter 8. Laboratory tests for microbiology. In "A manual of laboratory & diagnostic tests". J. J. Wu, C. M. Yeh, S. C. Hsieh, J. R. Wang, and T. M. Lin. p. 237-295. (in Chinese).
Stinson MW and Wang JR. 1998. Lectin inhibition of bacterial adhesion to animal cells. In Methods in Molecular Medicine: Vol. 9: Lectins: methods and protocols. J. M. Rhodes and J. D. Milton ed. Humana press Inc., N. J., U. S. A. p. 529-537.

Publication

Wang JR, Stinson MW. 1994. M protein mediates streptococcal adhesion to HEp-2 cells. Infect Immun 62: 442-448.
Wang JR, Stinson MW. 1994. Streptococcal M6 protein binds to fucose-containing glycoproteins on cultured human epithelial cells. Infect Immun 62: 1268-1274.
Liu JW, Wang JR, Su IJ, Wang YW, Ko WC, Chuang YC. 1996. Severe and mild form encephalitis diagnosed with polymerase chain reaction. J Inf Dis Soc R.O.C. 7: 23-28.
Chiu CP, Huo JH, Kuo Y, Wang JR. 1997. Numerical simulation of steady and pulsatile blood flow through an idealized stenosis. Chinese J Mechanics 13: 73-85.
Tsai PJ, Kuo CF, Lin KY, Lin YS, Lei HY, Chen FF, Wang JR, Wu JJ. 1998. Effect of group A streptococcal cysteine protease on invasion of epithelial cells. Infect Immun 66: 1460-1466.
Wang SM, Liu CC, Yang YJ, Yang HB, Lin CH, Wang JR. 1998. Fatal coxsackievirus B infection in early infancy characterized by fulminant hepatitis. J Infect 37: 270-273.
Tseng HW, Liu CC, Wang SM, Wang JR. 1999. The epidemic of enterovirus infection in southern Taiwan, 1998. Formos J Med 3: 75-81.
Wang SM, Liu CC, Tseng HW, Wang JR, Huang CC, Chen YJ, Yang YJ, Lin SJ, Yeh TF. 1999. Clinical spectrum of enterovirus 71 infection of children in southern Taiwan: emphasis on the neurological complications. Clin Infect Dis 29: 184-190.
Ho M, Chen ER, Hsu KH, Twu SJ, Chen KT, Tsai SF, Wang JR, Shih SR. 1999. An epidemic of enterovirus 71 infection in Taiwan. New Engl J Med 341: 929-935.
Hsiung GD, Wang JR. 2000. Enterovirus infections with special reference to enterovirus 71. J Microbiol Immunol Infect 33: 1-8.
Yan JJ, Wang JR, Liu CC, Gang HB, Su IJ. 2000. An outbreak of enterovirus 71 in Taiwan, 1998: a comprehensive pathological, virological and molecular study on a case of fulminant encephalitis. J Clin Virol 17(2): 13-22.
Liu CC, Tseng HW, Wang SM, Wang JR, Su IJ. 2000. An outbreak of enterovirus 71 in Taiwan, 1998: epidemiology and clinical manifestations. J Clin Virol 17(2): 23-30.
Wang JR, Tsai HP, Chen PF, Lai YJ, Yan JJ, Kiang D, Lin KH, Liu CC, Su IJ. 2000. An outbreak of enterovirus 71 in Taiwan, 1998: laboratory diagnosis and genetic analysis. J Clin Virol 17(2):91-100.
Yu CK, Chen CC, Chen CL, Wang JR, Liu CC, Yan JJ, Su IJ. 2000. Neutralizing antibody prevents enterovirus type 71 lethal challenge of neonatal mice. J Biomed Sci 7:523-528.
Lee PC, Hung CJ, Lei HY, Chang TT, Wang JR, Jan MS. 2000. Parvovirus B19-related acute hepatitis in an immunosuppressed kidney transplant. Nephrol Dial Transplant 15:1486-1488.
Tsai HP, Kuo PH, Liu CC, Wang JR. 2001. Respiratory viral infections among pediatric inpatients and outpatients in Taiwan from 1997 to 1999. J Clin Microbiol 39:111-118.
Yuan K, Chang CJ, Hsu PC, Sun HS, Tseng CC, Wang JR. 2001. Detection of putative periodontal pathogens in non-insulin-dependent diabetes mellitus and non-diabetes mellitus by polymerase chain reaction. J Periodont Res 36:18-24.
Yuan K, Hsu PC, Tseng CC, Kiang D, Wang JR. 2001. Detection rate of Actinobacillus actinomycetemcomitans on the permanent first molars of primary school children in Taiwan by polymerase chain reaction. J Clin Periodontol 28:348-352.
Chu PY, Lin KH, Hwang KP, Chou LC, Wang CF, Shih SR, Wang JR, Shimada Y, Ishiko H. 2001. Molecular epidemiology of enterovirus 71 in Taiwan. Arch Virol 146:589-600.
Yan JJ, Su IJ, Chen PF, Liu CC, Yu CK, Wang JR. 2001. Complete genome analysis of enterovirus 71 isolated from an outbreak in Taiwan and rapid identification of enterovirus 71 and coxsackievirus A 16 by RT-PCR. J Med Virol 65:331-339.
Shan YS, Lee PC, Wang JR, Tsai HP, Sung CM, Jin YT. 2001. Fibrosing cholestatic hepatitis possibly related to persistent parvovirus B19 infection in a renal transplant recipient. Nephrol Dial Transplant 16:2420-2422.
Wang JR, Tuan YC, Tsai HP, Yan JJ, Liu CC, Su IJ. 2002. Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000. J Clin Microbiol 40:10-15.
Lee PC, Hung CJ, Lin YJ, Wang JR, Jan MS, Lei HY. 2002. A role for chronic parvovirus B19 infection in liver dysfunction in renal transplant recipients? Transplantation 73: 1635-1639.
Wang JR, Tsai HP, Huang SW, Kuo PH, Kiang D, Liu CC. 2002. Laboratory diagnosis and genetic analysis of an echovirus 30 associated outbreak of aseptic meningitis in Taiwan in 2001. J Clin Microbiol 40: 4439-4444.
Wu SL, Wang JR, Chen HI, Lu LC, Chen HY, Twu SJ. 2002. Epidemiology of upper respiratory infection due to herpes simplex virus type 1 in children in Taiwan during 1997-1999. Public Health-Taiwan 21: 380-386.
Wang SM, Lei HY, Huang KJ, Wu JM, Wang JR, Yu CK, Su IJ, Liu CC. 2003. Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: role of cytokines and cellular immune activation in patients with pulmonary edema. J Infect Dis 188: 564-570.
Wang JR, Tsai HP, Kuo PH. 2004. Coronavirus and its Laboratory diagnosis. Journal of Infection Control 13(5): 281-286.
Wu WL, Wu LL, Wang JR, Tan KH, Chen HI, Chou WH, Hsu KH. 2004. Laboratory-based surveillance of upper respiratory infection due to enterovirus in children in Taiwan. Formosan J Med 8:293-299.
Wang YF, Chou CT, Lei HY, Liu CC, Wang SM, Yang JJ, Su IJ, Wang JR, Yeh TM, Chen SH, Yu CK. 2004. "A mouse-adapted enterovirus 71 strain causes neurological disease in mice after oral infection." J Virol 78(15): 7916-24.
Shih SR, Chen GW, Yang CC, Yang WZ, Liu DP, Liu JH, Chiu SC, Chen HY, Tsao KC, Huang CC, Huang YL, Mok CK, Chen CJ, Lin TY, Wang JR, Kao CL, Lin KH, Chen LK, Eng HL, Liu YC, Chen PY, Lin JS, Wang JH, Lin CW, Chan YJ, Lu JJ, Hsiung CA, Chen PJ, Su IJ. 2005. "Laboratory-based surveillance and molecular epidemiology of influenza virus in Taiwan." J Clin Microbiol 43(4): 1651-61.
Wang SM, Lei HY, Huang MC, Wu JM, Chen CT, Wang JN, Wang JR, Liu CC. 2005. "Therapeutic efficacy of milrinone in the management of enterovirus 71-induced pulmonary edema." Pediatr Pulmonol 39(3): 219-23.
Liu ML, Lee YP, Wang YF, Lei HY, Liu CC, Wang SM, Su IJ, Wang JR, Yeh TM, Chen S H, Yu CK. 2005. Type 1 interferons protect mice against enterovirus 71 infection. J Gen Virol 96: 3263-3269.
Weng TY, Chen LC, Shyu HW, Chen SH, Wang JR, Yu CK, Lei HY, Yeh TM. 2005. Lactoferrin inhibits enterovirus 71 infection by binding to VP1 protein and host cells. Antiviral Res 67: 31-37.
Lin KH, Hwang KP, Ke GM, Wang CF, Ke LY, Hsu YT, Tung YC, Chu PY, Chen BH, Chen HL, Kao CL, Wang JR, Eng HL, Wang SY, Hsu LC, Chen HY. 2006. "Evolution of EV71 genogroup in Taiwan from 1998 to 2005: an emerging of subgenogroup C4 of EV71." J Med Virol 78(2): 254-62.
Tsai HP, Wang HC, Kiang D, Huang SW, Kuo PH, Liu CC, Su IJ, Wang JR. 2006. "Increasing appearance of influenza B reassortment virus in Taiwan from 2002 to 2005." J Clin Microbiol 44: 2705-2713.
Wang SM, Liu CC, Wang HC, Su IJ, Wang JR. 2006. "Human metapneumovirus infection among children in Taiwan: A comparison of clinical manifestations with other virus-associated respiratory tract infections." Clin Microbiol Infect 12:1221-1224.
Wang SM, Lei HY, Su LY, Wu JM, Yu CK, Wang JR, and Liu CC. 2007. Cerebrospinal fluid cytokines in enterovirus 71 brain stem encephalitis and echovirus meningitis infections of varying severity. Clin Microbiol Infect 13: 677-82.
Chen CS, Tao YC, Lin SC, Lee YP, Wang YF, Wang JR, Liu CC, Lei HY, Yu CK. 2007. Retrograde axonal transport: a major transmission route of enterovirus 71 in mice. J Virol 81: 8996-9003.
Wu TC, Wang YF, Lee YP, Wang JR, Liu CC, Wang SM, Lei HY, Su IJ, and Yu CK. 2007. Immunity to avirulent enterovirus 71 and coxsackie A16 virus protect against enterovirus 71 infection in mice. J Virol 81:10310-10315.
Tseng FC, Huang HC, Chi CY, Lin TL, Liu CC, Jian JW, Hsu LC, Wu HS, Yang YJ, Chang YW, Wang HC, Hsu YW, Su IJ and Wang JR. 2007. Epidemiological survey of enterovirus infections occurring in Taiwan between 2000 and 2005. J Med Virol 79: 1850-1860.
Huang SC, Hsu YW, Wang HC, Huang SW, Kiang D, Tsai HP, Wang SM, Liu CC, Lin KH, Su IJ, and Wang JR. 2008. Appearance of intratypic recombination of enterovirus 71 in Taiwan from 2002 to 2005. Virus Research 131: 250-259.
Lee YR, Lei HY, Chen SH, Wang JR, Lin YS, Yeh TM, Liu CC, Liu HS. 2008. Signaling pathways involved in dengue-2 virus infection induced RANTES overexpression. American Infect Dis 4: 18-21.
Lee YR, Hung NT, Liu CC, Huang KJ, Lei HY, Lin YS, Wang JR, Yeh TM, Chen SH, Liu HS. 2008. Correlation of IFN-inducible protein 10 levels in sera with disease severity and clinical outcome of the dengue patients. American Infect Dis 4: 32-40.
Lee YR, Lei HY, Liu MT, Wang JR, Chen SH, Lin YS, Yeh TM, Liu CC, Liu HS. 2008. Autophagic machinery activated by dengue virus enhances virus replication. Virology 374: 240-248.
Wang SM, Lei HY, Yu CK, Wang JR, Su IJ, Liu CC. 2008. Acute chemokine response in the blood and cerebrospinal fluid of children with enterovirus 71-associated brainstem encephalitis. The Journal of Infectious Diseases 198:1002-1006.
Shen CF, Huang SC, Wang SM, Wang JR, Liu CC. 2008. Decreased leukocytes and other characteristics of laboratory findings of influenza virus infections in children. Journal of Microbiology, Immunology, and Infection 41:294-300.
Chi CY, Wang SM,; Lin CC, Wang HC, Wang JR, Su IJ, Liu CC. 2008. Clinical features of children infected with different strains of influenza B in southern Taiwan. The Pediatric Infectious Disease Journal 27:640-645.
Wang HC, Huang SW, Wang SW, Tsai HP, Kiang D, Wang SM, Liu CC, Su IJ, Wang JR. 2008. Co-circulating genetically divergent A2 human metapneumovirus strains among children in southern Taiwan. Arch Virol 153:2207-2213.
Liu TM, Chen HP, Wang LT, Wang JR, Luo TN, Chen YJ, Liu SI, Sun CK. 2009. Microwave resonant absorption of viruses through dipolar coupling with confined acoustic vibrations. Appl Phys Lett 94: 043902-1-043902-3.
Chi CY, Tseng FC, Liu DP, Chang YW, Wu HC, Huang YF, Hwang KP, Hsu YW, Wang SM, Liu CC, Wu HS, Yang JY, Yang CF, Wang JR*, Su IJ*. 2009. Investigations of clinical isolations of oral poliovirus vaccine strains between 2000 and 2005 in southern Taiwan. J Clin Virol 45(2):129-34.
Huang SW, Hsu YW, Smith DJ, Kiang D, Tsai HP, Lin KH, Wang SM, Liu CC, Su IJ, Wang JR. 2009. Reemergence of enterovirus 71 in 2008 in Taiwan: dynamics of genetic and antigenic evolution from 1998 to 2008. J Clin Microbiol 47(11):3653-3662.
Kung YH, Huang SW, Kuo PH, Kiang D, Ho MS, Liu CC, Yu CK, Su IJ, Wang JR. 2010. Introduction of a strong temperature-sensitive phenotype into enterovirus 71 by altering the amino acid of virus 3D polymerase. Virology 396: 1-9.
Su WJ, Shao PL, Liu MT, Liu DP, Huang KC, Chang LY, Lu CY, Wang JR, Shih SR, Huang DT, Chi H, Huang LM. 2010. Low seroprotection against preseasonal influenza local strains in children might predict the upcoming epidemic influenza strains. Clin Infect Dis. 51:171-6.
Chi CY, Liu CC, Lin CC, Wang HC, Cheng YT, Chang CM, Wang JR. 2010. Pre-existing Antibody Response against 2009 Pandemic Influenza H1N1 Viruses in Taiwanese Population. Clin Vaccine Immunol 17(12):1958-1962.
Wang SM, Ho TS, Shen CF, Wang JR, Liu CC. 2011. Echovirus 18 meningitis in southern Taiwan. Pedictr Infect Dis J. 30(3):259-260.
Tsai HP, Wang JR. 2011. Influenza viruses and 2009 H1N1 pandemic influenza virus. Formosan J Med 15(3): 252-260 (invited review).
Ke GM, Lin KH, Lu PL, Tung YC, Wang CF, Ke LY, Lee MS, Lin PC, Su HJ, Lin YY, Huang TP, Huang TP, Wang JR, Wang SY, Hsu LC, Chu PY. 2011. Molecular epidemiology of Echovirus 30 in Taiwan, 1988-2008. Virus Genes 42(2):178-188.
Lao WI, Wang YF, Kuo YD, Lin CH, Chang TC, Su IJ, Wang JR, Chang CF. 2011. Profiling of influenza viruses by high-throughput carbohydrate membrane array. Fut Med Chem 3:283-296.
Huang DT, Shao PL, Huang KC, Lu CY, Wang JR, Shih SR, Chi H, Lai MR, Lee CY, Chang LY, Huang LM. 2011. Serologic status for pandemic (H1N1) 2009 virus, Taiwan. Emerg Infect Dis. 17(1):76-78.
Huang SW, Kiang D, Smith DJ, and Wang JR. 2011. Evolution of re-emergent virus and its impact on enterovirus 71 epidemics. Exp Biol Med 236:899-908.
Tsai HP, Huang SW, Wu FL, Kuo PH, Wang SM, Liu CC, Su IJ, Wang JR. 2011. A genetic variant echovirus 18 associated with outbreak of aseptic meningitis in Taiwan. J Med Microbiol 60(9):1360-1365. (figure on cover)
Yeh MT, Wang SW, Yu CK, Lin KH, Lei HY, Su IJ, Wang JR. 2011. A single nucleotide in stem loop II of 5´-untranslated region contributes to virulence of enterovirus 71 in mice. PLoS ONE 6(11):e27082.
Huang SW, Wang YF, Yu CK, Su IJ, Wang JR. 2012. Mutations in VP2 and VP1 capsid proteins increase infectivity and mouse lethality of enterovirus 71 by virus binding and RNA accumulation enhancement. Virology 422:132-143.
Wang YF, Chang CF, Chi CY, Wang HC, Wang JR, Su IJ. 2012. Characterization of glycan binding specificities of influenza B viruses with correlation with hemagglutinin genotypes and clinical features. J Med Virol 84(4):679-685.
Wang SM, Ho TS, Lin HC, Lei HY, Wang JR, Liu CC. 2012. Reemerging of enterovirus 71 in Taiwan: the age impact on disease severity. Eur J Clin Microbiol Infect Dis31:1219-1224.
Cheng LW, Huang SW, Huang LM, Chang LY, Shao PL, Kiang D, Wang JR. 2012. Comparison of neutralizing and hemagglutination-inhibiting antibody responses for evaluating the seasonal influenza vaccine. J Virol Methods 182: 43-49.
Chang YT, Guo CY, Tsai MS, Cheng YY, Lin MT, Chen CH, Shen D, Wang JR*, Sung JM*. Poor immune response to a standard single dose non-adjuvanted vaccination against 2009 pandemic H1N1 influenza virus A in the adult and elder hemodialysis patients. 2012. Vaccine 30(33):5009-5018.
Wang YF, Lao WI, Kuo YD, Guu SY, Wang HC, Lin CH, Wang JR, Su IJ, Chang CF. 2012. Receptor binding surveillance of influenza clinical isolates. Future Virol 7(6): 621-633.
Lee MS, Tseng FC, Wang JR, Chi CY, Chong P, Su IJ. 2012. Challenges to licensure of enterovirus 71 vaccines. PLoS Negl Trop Dis 6(8): e1737.doi:10.1371/journal.pntd.0001737.
Chou AH, Liu CC, Chang JY, Lien SP, Guo MS, Tsai HP, Hsiao KN, Liu SJ, Sia C, Wu SC, Lee MS, Hsiao CH, Wang JR, Chow YH, Chong P. 2012. Immunological evaluation and comparison of different EV71 vaccine candidates. Clinical and Developmental Immunology 2012, Article ID 831282, 8 pages. doi:10.1155/2012/831282.
Su PY, Liu YT, Chang HY, Huang SW, Wang YF, Yu CK, Wang JR, Chang CF. 2012. Cell surface sialylation affects binding of enterovirus 71 to rhabdomyosarcoma and neuroblastoma cells. BMC Microbiology12: e162.
Chong P, Guo MS, Lin FHY, Hsiao KN, Weng SY, Chou AH, Wang JR, Hsieh SY, Su IJ, Liu CC. 2012. Immunological and biochemical characterization of coxsackie virus A16 viral particles. PLoS ONE 7(11): e49973.
Lee YP, Wang YF, Wang JR, Huang SW, Yu CK. 2012. Enterovirus 71 blocks selectively type I interferon production through the 3C viral protein in mice. J Med Virol 84: 1779-1789.
Wang, SM, Tsai MH, Lei HY, Wang JR, Liu CC. 2012. The regulatory T cells in anti-influenza antibody response post influenza vaccination. Human vaccines & immunotherapeutics 8(9):1243-9.
Van Kerkhove MD, Hirve S, Koukounari A, Mounts AW; for the H1N1pdm serology working group. 2013. Estimating age-specific cumulative incidence for the 2009 influenza pandemic: a meta-analysis of A(H1N1)pdm09 serological studies from 19 countries. Influenza Other Respi Viruses 7(5): 872-886.
Chi CY, Khanh TH, Thoa le PK, Tseng FC, Wang SM, Thinh le Q, Lin CC, Wu HC, Wang JR, Hung NT, Thuong TC, Chang CM, Su IJ, Liu CC. 2013. Milrinone therapy for enterovirus 71-induced pulmonary edema and/or neurogenic shock in children: a randomized controlled trial. Crit Care Med 41(7):1754-60.
Chuang YC, Lin YS, Liu HS, Wang JR, Yeh TM. 2013. Antibodies against thrombin in dengue patients contain both anti-thrombotic and pro-fibrinolytic activities. Thromb Haemost 110(2):358-65.
Wang SL, Chi CY, Kuo PH, Tsai HP, Wang SM, Liu CC, Su IJ, Wang JR. 2013. High-incidence of human adenoviral co-infections in Taiwan. PLoS ONE 8(9): e75208. doi:10.1371/journal.pone.0075208.
Chou AH, Liu CC, Chang JY, Jiang R, Hsieh YC, Tsao A, Chien-Long Wu CL, Huang JL, Fung CP, Hsieh SM, Wang YF, Wang JR, Hu MH, Chiang JR, Su IJ, Chong PCS. 2013. Formalin-inactivated EV71 vaccine candidate induced cross-neutralizing antibody against subgenotypes B1, B4, B5 and C4A in adult volunteers. PLoS ONE 8(11): e79783.
Thoa LPK, Chiang PS, Khanh TH, Luo ST, Dan TNH, Wang YF, Thuong TC, Chung WY, Hung NT, Wang JR, Nhan LNT, Thinh LQ, Su IJ, Dung TD, Lee MS. 2013. Genetic and antigenic characterization of enterovirus 71 in Ho Chi Minh city, Vietnam, 2011. PLoS ONE 8(7):e69895. DOI:10.1371/journal.pone.0069895.
Linsuwanon P, Puenpa J, Huang SW, Wang YF, Mauleekoonphairoj J, Wang JR, Poovorawan Y. 2014. Epidemiology and seroepidemiology of human enterovirus 71 among Thai populations. J Biomedical Science 21(1):16. DOI:10.1186/1423-0127-21-16.
Huang SW, Cheng HL, Hsieh HY, Chang CL, Tsai HP, Kuo PH, Wang SM, Liu CC, Su IJ, Wang JR. 2014. Mutations in the non-structural protein region contribute to intra-genotypic evolution of enterovirus 71. J Biomed Sci. 21:33. doi: 10.1186/1423-0127-21-33.
Wang SM, Liao YT, Hu YS, Ho TS, Shen CF, Wang JR, Lin YS, Liu CC. Immunophenotype expressions and cytokine profiles of influenza A H1N1 virus infection in pediatric patients in 2009. 2014. Dis Markers 2014:195453. doi: 10.1155/2014/195453. Epub 2014 Feb 18.
Lee YR, Wang PS, Wang JR, Liu HS. 2014. Enterovirus 71-induced autophagy increases viral replication and pathogenesis in a suckling mouse model. J Biomed Sci. 2014 Aug 20;21(1):80. [Epub ahead of print]
Liu CC, Hwang CS, Yang WS, Tsai DC, Wu SH, Chou AH, Chow YH, Wu SC, Wang JR, Chiang JR, Huang CC, Pan CH, Chong P. 2014. Long-term immunogenicity studies of formalin-inactivated enterovirus 71 whole-virion vaccine in macaques. PLoS ONE 9(9): e106756. doi:10.1371/journal.pone.0106756
Hung JH, Chu CY, Lee CN, Hsu CK, Lee JY, Wang JR, Chang KC, Huang FC. 2015. Conjunctival geographic ulcer: an overlooked sign of herpes simplex virus infection. J Clin Virol. 2015 Mar;64:40-44.
Su PY, Wang YF, Huang SW, Lo YC, Wang YH, Wu SR, Shieh DB, Chen SH, Wang JR, Lai MD, Chang CF. 2015. Cell surface nucleolin facilitates enterovirus 71 binding and infection. J Virol. 89(8):4527-38.
Liao YT, Wang SM, Wang JR, Yu CK, Liu CC. 2015. Norepinephrine and epinephrine enhanced the infectivity of enterovirus 71. PLoS One 10(8):e0135154.
Shih HI, Wang HC, Su IJ, Hsu HC, Wang JR, Sun HF, Chou CH, Ko WC, Hsieh MI, Wu CJ. 2015. Viral respiratory tract infections in adult patients attending outpatient and Emergency Departments, Taiwan, 2012-2013: A PCR/electrospray ionization mass spectrometry study. Medicine (Baltimore). 2015 Sep;94(38):e1545. doi: 10.1097/MD.0000000000001545.
Huang SW, Tai CH, Fonville JM, Lin CH, Wang SM, Liu CC, Su IJ, Smith DJ, Wang JR. 2015. Mapping enterovirus A71 antigenic determinants from viral evolution. J Virol Nov 15;89(22):11500-6.
Lim MC, Wang YF, Huang SW, Yang JY, Wang JR. 2015. High incidence of mammalian orthoreovirus identified by environmental surveillance in Taiwan. PLoS One. Nov 10;10(11):e0142745. doi: 10.1371/journal.pone.0142745.
Wang YF, Shen FC, Wang SL, Kuo PH, Tsai HP, Liu CC, Wang JR, Chi CY. 2016. Molecular epidemiology and clinical manifestations of adenovirus respiratory infections in Taiwanese children. Medicine (Baltimore). 2016 May; 95(18):e3577.
Kuo MT, Fang PC, Yu HJ, Chao TL, Chien CC, Chen SH, Wang JR, Tseng SL, Lai YH, Hsiao CC, Chang TC. 2016. A multiplex dot hybridization assay for detection and differentiation of acanthamoeba and herpes keratitis. Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):2158-63.
Tsai HP, Tsai YY, Lin IT, Kuo PH, Chen TY, Chang KC, Wang JR. 2016. Comparison of two commercial automated nucleic acid extraction and integrated quantitation Real-Time PCR platforms for the detection of cytomegalovirus in plasma. PLoS One. 2016 Aug 5;11(8):e0160493. doi: 10.1371/journal.pone.0160493.
Tsai HP, Tsai YY, Lin IT, Kuo PH, Chang KC, Chen JC, Ko WC, Wang JR. 2016. Validation and application of a commercial quantitative real-time reverse transcriptase-PCR Assay in investigation of a large dengue virus outbreak in southern Taiwan. PLOS Negl Trop Dis http://dx.doi.org/10.1371/journal.pntd.0005036

Conference Paper

Wang JR, Stinson MW. 1991. M protein mediates adherence of Streptococcus pyogenes to human epithelial cells. Buffalo Conference on Microbial Pathogenesis, Buffalo, NY, April.
Wang JR, Stinson MW. 1992. Interaction of streptococcal M protein with cultured human epithelial cells. The 92nd general meeting of the American Society for Microbiology, New Orleans, Louisiana, May 26-30. Abstract D181. p. 126.
Wang JR, Stinson MW. Streptococcal M6 protein binds to fucose-containing glycoproteins on cultured human epithelial cells. 1993. The 93rd general meeting of the American Society for Microbiology, Atlanta, Georgia, May 16-20. Abstract B199. p. 61.
Wang JR, Sathyakumar C, Amsterdam D. 1994. Comparative in vitro susceptibility and cross resistance of Gram-negative bacteremic isolates. The 94th general meeting of the American Society for Microbiology, Las Vegas, Nevada, May 23-27. Abstract A50. p. 10.
Wang JR, Misra SR, Sathyakumar C, Razeq J, Amsterdam D. 1994. Time to detection of seeded blood cultures monitored by infrared and fluorescent systems. The 94th general meeting of the American Society for Microbiology, Las Vegas, Nevada, May 23-27. Abstract C68. p. 502.
Wang JR. 1995. Quantitation of cytomegalovirus DNA by polymerase chain reaction and DNA enzyme immunoassay. The 1996 annual meeting of the Chinese Society of Medical Technology, Taipei, Taiwan. Nov. 3. .J of Biomedical & Laboratory Sciences 7(4): A74.
Wang JR. 1996. Diagnostic strategies for cytomegalovirus infections. Second international symposium on diagnosis of viral and chlamydial infections, Tainan, Taiwan, March 31-April 2. p.19-1 to 19-8.
Tai HY, Wang JR. 1996. Adherence of Streptococcus pneumoniae to respiratory syncytial virus infected Cells. The 30th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan. Abstract BM-6. CSM-3.
Wang JR. 1997. Functions and problems of a clinical virology laboratory. Symposium on clinical virology and bacteriology, Tainan, Taiwan, March 15-16. p. 21-22.
Wang JR, Kuo PH, Yee JJ, Chen MY, Su IJ. 1997. Seasonal variations of viral activity in Tainan Taiwan. The 13th Clinical Virology Symposium, Clearwater Beach, Florida, April 27-30. Abstract T5.
Wang JR. 1997. Adherence of Streptococcus pneumoniae to respiratory syncytial virus infected cells. The 97th general meeting of the American Society for Microbiology, Miami Beach, Florida, May 4-8. Abstract B458. p. 107.
Tsai PJ, Lin KY, Kuo CF, Lei YH, Lin YS, Wang JR, Wu JJ. 1997. Role of streptococcal pyrogenic exotoxin B in Streptococcus pyogenes entry into epithelial cells. The 97th general meeting of the American Society for Microbiology, Miami Beach, Florida, May 4-8. Abstract B53. p. 37.
Chen HY, Wang JR, Wu SL, Kuo PH, Su IJ, Wang GR. 1997. Virological surveillance of influenza in Taipei and Tainan. The 1997 annual meeting of the Chinese Society of Medical Technology, Taipei, Taiwan, Oct. 5. Abstract B16. p.58.
Wang YF, Wang GJ, Yang CY, Wang JR. 1997. Respiratory syncytial virus infection enhances bacterial adhesion. The 31th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Dec. 7. Abstract V-1.
Wang YS, Wang GJ, Yang CY, Wang JR. 1997. Interaction of respiratory syncytial virus with cultured human epithelial cells. The 31th annual meeting of the Chinese Society of Microbiology. The Chinese Society of Microbiology, Taipei, Taiwan, Dec. 7. Abstract V-2.
Wang JR. 1997. Interaction of respiratory syncytial virus and cultured human epithelial cells. 4th Asia-Pacific Congress of Medical Virology, Nov. 3-5. Abstract p.122.
Wang JR, Yu CK, Wang GJ, Wang YF. 1998. Effect of respiratory syncytial virus infection on bacterial adhesion in vivo. Abstract for 98th general meeting of the American Society for Microbiology, Atlanta, Georgia, May 17-21. Abstract C388. p. 196.
Wu JJ, Chang BW, Cheng WS, Wang JR, Chang HC. 1998. Examine the effect of respiratory syncytial virus infection on pneumococci to HEp-2 cells and BMK cells by atomic force microscopy. 4th Young Asian Biochemical Engineers’ Community Symposium on the Biotechnology, Nov. 28-30.
Kuo PH, Tsai HP, Yan JJ, Wang SM, Liu CC, Su IJ, Wang JR. 1998. Enterovirus epidemic and typing analysis in Tainan, 1998. The 1998 annual meeting of the Chinese Society of Medical Technology, Taipei, Taiwan, Oct. 25.
Tsai HP, Lai YJ, Wang YF, Liu CC, Su IJ, Huang KY, Wang JR. 1998. Comparison on identification of enterovirus 71 and coxsackievirus A16. The 32th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Nov. 26-30. Abstract V-3. CSM-87.
Cheng HY, Lin CC, Lin TC, Wang JR. 1998. Antiviral activity of punicalagin and punicalin from the leaf of Terminalia catappa L. The 32th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Nov. 26-30. Abstract V-22. CSM-96.
Wang JR. Laboratory diagnosis and genetic analysis of enterovirus 71. 1999. Third International Symposium on Viral and Chlamydial Infections, Tainan, Taiwan, March 12-13.
Wang JR, Cheng HY, Lin TC, Lin CC. 1999. Antiviral activity of punicalagin and punicalin from the leaf of Terminalia catappa L. The 99th general meeting of the American Society for Microbiology, Chicago, Illinois, May 30-June 3. Abstract S17, p. 626.
Wang JR. 1999. Enterovirus 71 epidemic in Taiwan-clinical manifestations, epidemiology, laboratory diagnosis and genetic analysis. The Korean Society of Clinical Pathologists, The 4th Honam and Youngnam Joint Conference, Korea, June 19.
Wang JR, Tsai HP, Chen PF, Lai YJ, Su IJ. 1999. Laboratory diagnosis and genetic analysis of 1998 enterovirus 71 isolates in Taiwan. XIth International Congress of Virology, Sydney, Australia, Aug. 9-13.
Chen PF, Yan JJ, Lai YR, Tsai HP, Su IJ, Wang JR. 1999. Rapid identification of enterovirus 71 and coxsackievirus A16 by RT-PCR. The 4th Chinese Laboratory Medicine Conference, Taipei, Taiwan, Oct. 22-24.
Chen PF, Liu CC, Su IJ, Wang JR. 1999. Molecular Epidemiology of 1998 Enterovirus 71 isolates in Taiwan. The 33rd annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Dec. 5. Abstract V-1.
Lin WH, Wang JR. 1999. Interaction between enterovirus 71 and neuronal cells: heparin/heparan sulfate mediates the viral attachment. The 33rd annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Dec. 5. Abstract V-3.
Kuo PH, Liu CC, Su IJ, Wang JR. 1999. Induction of apoptosis in neuronal cells by enterovirus 71. The 33rd annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Dec. 5. Abstract V-5.
Wang JR, Yan JJ, Chen PF, Tsai HP, Su IJ. 2000. Rapid identification of enterovirus 71 and coxsackievirus A16 by RT-PCR. The 16th Clinical Virology Symposium, Clearwater Beach, Florida, April 30-May 3. Abstract M26.
Kuo PH, Tsai HP, Chen PF, Yu JS, Tuan YC, Wang JR. 2000. Analysis of enterovirus 71 isolated from 1998 to 2000. The 34th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Dec. 3.
Tsai HP, Yan JJ, Wang JR. 2000. Comparison of primer sets for detection of enterovirus 71 from clinical specimens by RT-PCR. The 34th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Dec. 3.
Shen WY, Lin WH, Yu JS, Wang JR. 2000. Role of VP1 protein in enterovirus 71 binding to cell surface heparan sulfate. The 34th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Dec. 3.
Tuan YC, Liu CC, Wang JR. 2000. Antiviral effect of nitric oxide on enterovirus 71 replication. The 34th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Dec. 3.
Wang JR, Tuan YC, Chen PF, Yu JS, Tsai HP, Kuo PH. 2001. Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and mouth disease in Taiwan between 1998 and 2000. The 17th Clinical Virology Symposium, Clearwater Beach, Florida, April 29-May 2. Abstract S43.
Wang JR. 2001. Diagnostic and molecular virology of enterovirus 71. The 9th SCBA International Symposium. Society of Chinese Bioscientists in America, Aug. 6-10.
Tsai HP, Huang SW, Kuo PH, Wang JR. 2001. Echovirus 30 associated with outbreak of aseptic meningitis in Taiwan in 2001. The 2001 annual meeting of the Chinese Society of Medical Technology, Taipei, Taiwan, Oct. 21.
Wang JR. 2001. Foot-and-mouth disease and enterovirus. 2001 Annual Meeting of the Society of Medicine, Nov. 11.
Wang JR. 2001. Enterovirus outbreaks between 1998 and 2001. Symposium on new advances in virology and parasitology, Dec. 9.
Kuo PH, Liu CC, Wang JR. 2001. Virological properties of enterovirus 71 isolated form various clinical presentations. The 35th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Dec. 16.
Huang SW, Tsai HP, Kuo PH, Wang JR. 2001. Genetic analysis of echovirus associated with outbreak of aseptic meningitis in Taiwan in 2001. The 35th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Dec. 16.
Wang JR, Wu JJ, Muldoon S, Rood H, Schachter J, Jang D, Pinson J, Cheng YM, Chang CH, Chang FM, Chernesky M. 2001. Ability of the LCx assay to detect Chlamydia trachomatis and Neisseria gonorrhoeae in cervical swabs and urines from women attending a university women’s clinic in Tainan, Taiwan. ICAAC, Chicago, Illinois, Dec 16-19.
Wang JR, Wu JJ, Chang AL, Hsu HM, Chang CH, Schachter J, Jang D, Cheng YM, Chang FM, Chernesky MA. 2002. C. trachomatis- and N. gonorrhoeae- infections detected by ligase chain reaction (LCR) of cervical swabs and urine in women attending STD or gynecology clinics in Taiwan. International Congress on Infectious Diseases, Singapore, March 11-14.
Wang JR, Tsai HP, Huang SW, Kuo PH. 2002. Echovirus 30 associated with outbreak of aseptic meningitis in Taiwan in 2001. The 18th Clinical Virology Symposium, Clearwater Beach, Florida, April 28- May 1.
Wang JR, Tsai HP, Huang SW, Kuo PH, Liu CC. 2002. Molecular analysis of echovirus 30 associated with outbreak of aseptic meningitis in Taiwan in 2001. XIIth International Congress of Virology, Paris, France, July 27-Aug. 1.
Huang SW, Tsai HP, Kuo PH, Wang JR. 2002. Analysis of echovirus 6 associated with outbreak of aseptic meningitis in Taiwan in 2001. The 2002 annual meeting of the Chinese Society of Medical Technology, Taipei, Taiwan, Nov. 3.
Tsai HP, Huang SW, Kuo PH, Wang JR. 2002. Molecular evolution of influenza A/H3N2 viruses in southern Taiwan during 1999-2002. The 36th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Dec. 15.
Tsai HP, Huang SW, Kuo PH, Liu CC, Wang JR. 2003. Screening of amantadine-resistant influenza A virus in Southern Taiwan. Current status & challenge of infectious disease in Asia, NHRI/NCKU, Feb. 21-22.
Huang SW, Hsu YW, Tsai HP, Kuo PH, Liu CC, Wang JR. 2003. Genetic analysis of coxsackievirus A10 associated with herpangina outbreak in Taiwan. Current status & challenge of infectious disease in Asia, NHRI/NCKU, Feb. 21-22.
Wang JR, Tsai HP, Kuo PH, Wang SM, Liu CC. 2003. Laboratory-supported influenza surveillance in southern Taiwan sentinel general practices from 1999 to 2002. Options for Influenza Control V, Okinawa, Japan, Oct. 7-11.
Tsai HP, Chou WB, Hsu YW, Kuo PH, Wang JR. 2003. Comparison of three commercial rapid diagnosis kits and realtime RT-PCR for rapid detection of influenza virus from clinical specimens. The 37th annual meeting of the Chinese Society of Microbiology, Taichung, Taiwan, Dec. 7.
Wang JR, Huang SW, Tsai HP, Kuo PH. 2004. Molecular analysis of an echovirus 6 associated outbreak of aseptic meningitis. The 20th Annual Clinical Virology Symposium, Clearwater Beach, Florida, April 25- 28.
Wang JR. 2004. Role of Sentinel Surveillance in influenza outbreaks. 2004 Asia Pacific Intercity Symposium on influenza Control and Prevention. Taipei, Taiwan, May 22.
Wang JR, Tsai HP, Huang SW, Kuo PH, Liu CC. 2005. Genetic and antigenic characterization of influenza B viruses isolated in Taiwan from 1998 to 2004. XIII International Congress of Virology. San Francisco, California, July 23-28.
Shih SR, Chen GW, Wang JR, Kao CL, Lin KH, Chen LK, Eng HL, Liu YC, Chen PY, Lin JS, Lin CW, Chan YJ, Chen PJ, Su IJ. 2005. Laboratory-based surveillance and molecular epidemiology of influenza virus in Taiwan. XIII International Congress of Virology. San Francisco, California, July 23-28.
Lin KH, Kel GM, Wang CF, Ke LY, Hsu YT, Chu PY, Tung YC, C BH, Kao CL, Wang JR, Eng HL, Wang S, Hsu LC, Chen HY. 2005. The changing of EV71 genogroup in Taiwan during 1998-2004 ~an emerging of subgenogroup CA of EV71. XIII International Congress of Virology. San Francisco, California, July 23-28.
Kung YH, Wang JR. 2005. The effect of 3D polymerase mutation in enterovirus 71 replication. The 39th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Dec. 25.
Wang JR. 2006. Enterovirus 71 and its pathogenicity. Pasture/NHRI/CDC Symposium on Re-emerging Virus Infections, Taiwan, Taiwan Sep. 1-3.
Tsai HP, Wu FL, Huang SW, Liu CC, Wang JR. 2006. Typing and genetic analysis of echovirus 18 associated aseptic meningitis in Taiwan in 2006. The 40th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Nov. 18.
Lee PY, Wang HC, Wang LT, Wang JR. 2007. Genetic analysis of M and NP genes of human influenza A isolates from 2002 to 2006 in Taiwan. The 22th Joint Annual Conference of Biomedical Sciences, Taipei, March 17-18.
Tsai HP, Wu FL, Huang SW, Kuo PH, Liu CC, Wang JR. 2007. Laboratory diagnosis and genetic analysis of echovirus 18 associated aseptic meningitis in Taiwan in 2006. The 23th Annual Clinical Virology Symposium and annual meeting Pan American Society for Clinical Virology, Clearwater Beach, Florida, April 29- May 2.
Wang LT, Wang JR. 2007. The effect of NS1 genetic variation of H1N1 influenza virus against type I interferon. The 40th annual meeting of the Chinese Society of Microbiology, Taipei, Taiwan, Dec. 16.
Huang SW, Hsu YW, Su IJ, Wang JR. 2008. Dynamics of EV71 Genetic and Antigenic Evolution from 1998 to 2007 in Taiwan. XIV International Congress of Virology. Istanbul, Turkey, Aug. 10-15.
Huang SW, Wang YF, Yu CK, Su IJ, Wang JR. 2008. Capsid proteins contribute to the neurotoxicity and virulence of enterovirus 71. XIV International Congress of Virology. Istanbul, Turkey, Aug. 10-15.
Wang JR. 2008. Returning of EV71: epidemiology and genetic analysis”. Taiwan-Singapore Minisymposium on Reemerging of Enterovirus 71. Tainan, July 23, 2008.
Huang SW, Hsu YW, Wang JR. 2008. Current status of Enterovirus 71. Symposium on Enterovirus 71 Prevention & Control. 2008 Annual Meeting of the Taiwan Public Health Association. Taipei, Oct. 4-5, 2008.
Wang JR. Understanding and researching the enterovirus 71 and its pathogenicity for better prevention”, Pandemic Influenza and Enterovirus Preparedness & Control. Hong Kong, Sep. 18-19, 2008.
Hsu YW, Wang JR. 2008. Human and avian influenza viruses. Symposium on Influenza Preparedness & Control. 2008 Annual Meeting of the Taiwan Society of Internal Medicine. Taipei, Nov. 29, 2008.
Cheng LW, Huang SW, Liu CC, Huang LM, Wang JR. 2008. Examination of the antigenic difference of circulating H1N1 influenza A viruses. The 19th annual meeting of the Taiwan Society of Microbiology. 11th Western Pacific Congress on Chemotherapy and Infectious Diseases. Taipei, Taiwan, Nov. 29-Dec. 3, 2008.
Wang JR, Kung YH, Huang SW, Su IJ. 2009. Introduction of a strong temperature-sensitive phenotype into enterovirus 71 by altering the amino acid of virus 3D polymerase. 8th Asia Pacific Congress of Medical Virology. Hong Kong SAR, China. Feb. 25-28, 2009.
Wang JR. 2009. Genetic and antigenic analyses of enterovirus 71. 8th Asia Pacific Congress of Medical Virology. Hong Kong SAR, China. Feb. 25-28, 2009.
Wang JR. 2009. Genetic and antigenic analyses of enterovirus 71. Taiwan-Swiss Biomedical Symposium. Yilan, Taiwan. June 10-11, 2009.
Wang JR, Huang SW, Kung YH, Liu CC, Yu CK, Su IJ. Molecular epidemiology and genetic analysis of enterovirus 71. Indo-Taiwanese workshop on Infectious Diseases. Indian Institute of Science, Bangalore. Nov. 27-28, 2009.
Chen JM, Wang JR. 2009. The virology of seasonal influenza and 2009 pandemic influenza A (H1N1). Seminars on Seasonal Influenza and Pandemic Influenza H1N1. 2009 Annual Meeting of the Taiwan Society of Internal Medicine. Taipei, Nov. 8, 2009.
Kung YH, Tsai HP, Kuo PH, Wang SY, Ko CW, Yan JJ, Wang JR. 2009. Evaluation of two rapid antigen tests for detection of influenza virus. The 2009 annual meeting of the Chinese Society of Medical Technology, Taipei, Taiwan, Nov. 8, 2009.
Dai JH, Huang SW, Wang JR. 2009. Antigenic variations among different genotypes of enterovirus 71. The 19th annual meeting of Taiwan Society of Microbiology, Taipei, Taiwan, Dec. 13.
Wang JR, Huang SW, Kung YH. 2010. Enterovirus 71 outbreaks from 1998 to 2009-unravel 1998 EV71 epidemic”. The 18th Annual Meeting of the Chinese Society of Cell and Molecular Biology. Kenting, Taiwan. Jan. 20-22, 2010.
Huang SW, Wang YF, Yu CK, Wang JR. 2010. VP1 and VP2 capsid proteins contributed to neurotoxicity and virulence of enterovirus 71. UK Society for General Microbiology Spring 2010 Meeting, Edinburgh, England. March 29-April 1, 2010.
Cheng LW, Huang SW, Wang JR. 2010. Comparison of neutralizing and hemagglutination-inhibiting antibody responses for evaluating the seasonal influenza vaccine. Options for the Control of Influenza VII, Hong Kong. Sep.3-7, 2010.
Huang SW, Kung YH, Liu CC, Yu CK, Su IJ, Wang JR. 2010. Lessons from enterovirus 71 epidemics: evolution of reemerging viruses and its impact. The 2nd International Vaccine Symposium “Vaccine from Research to Product Launch“. Miaoli, Taiwan. Oct. 7-8, 2010.
Huang SW, Wang YF, Yu CK, Wang JR. 2010. “Mutations in VP2 and VP1 capsid proteins increase cytotoxity and mouse lethality of enterovirus 71”. Symposium on Receptor, Immunopathogenesis, and Therapy of Enterovirus 71 Infection. Tainan, Taiwan. Oct. 9, 2010.
Kuo PH, Wang HI, Tsai HP, Kung YH, Ko CW, Lee PC, Lin YJ, Wang JR. 2010. Establishment of a routine monitoring assay of polyomavirus BK in a clinical laboratory. Cross-strait Laboratory Medicine Symposium in 2010. Oct. 30-31.
Lim MCY, Wang JR. 2010. Analysis of binding property of pandemic and seasonal H1N1 influenza viruses. The 20th annual meeting of Taiwan Society of Microbiology, Taipei, Taiwan, Dec. 11.
Liu SY, Huang SW, Wang JR. 2010. Characterize the effect of the VP145E and VP2149M mutations of enterovirus 71 on RNA replication. The 20th annual meeting of Taiwan Society of Microbiology, Taipei, Taiwan, Dec. 11.
Tai CH, Huang SW, Wang JR. 2011. VP1 contributed to antigenic variations among different genotypes of enterovirus 71. 21st Annual Meeting of the Society for Virology. Freiburg, Germany. March 23-26.
Yeh MT, Wang JR. 2011. A short fragment in the 5'-UTR of Enterovirus 71 determined viral translation and virulence in mice. 21st Annual Meeting of the Society for Virology. Freiburg, Germany. March 23-26.
Yeh MT, Wang JR. 2011. A short fragment in the 5'-UTR of Enterovirus 71 determined viral translation and virulence in mice. Forth Asia-Pacific City Forum of Biomedical Laboratory Science. Tainan, Taiwan. April 30-May 1.
Kung YH, Kuo PH, Tsai HP, Ko CW, Wang HY, Chien ML, Chen HM, Yan JJ, Wang JR. 2011. Reduction in the overall contamination rate for virus culture. Forth Asia-Pacific City Forum of Biomedical Laboratory Science. Tainan, Taiwan. April 30-May 1.
Tsai HP, Wang SY, Kuo PH, Ko CW, Kung YH, Yan JJ, Wang JR. 2011. Evaluation of different rapid molecular diagnosis methods in detection of pandemic influenza type A virus (pH1N1). Forth Asia-Pacific City Forum of Biomedical Laboratory Science. Tainan, Taiwan. April 30-May 1. Received Distinguished Paper Award-Poster Presentation.
Cheng LW, Huang SW, Wang JR. 2011. Examination of antigenic differences of human seasonal influenza A/H1N1 viruses. Kyestone Symposia on Molecular and Cellular Biology. Pathogenesis of Influenza: Virus-Host Interaction. Hong Kong. May 23-28.
Huang SW, Kung YH, Liu CC, Yu CK, Su IJ and Wang JR. 2011. Lessons from enterovirus 71 epidemics: evolution of reemerging viruses and its impact. The 13th SCBA International Conference in Guangzhou, China. July 25-29.
Huang SW, Liu CC, Yu CK, Su IJ and Wang JR. 2011. Antigenic evolution of EV71 and impact on vaccine development. The 1st International Symposium of Vaccine Development against Human Hand-Foot-and-Mouth Diseases. Zhunan, Taiwan. Sep. 4-5.
Huang SW, Wang YF, Yu CK, Su IJ, Wang JR. 2011. Mutations in VP2 and VP1 capsid proteins increase infectivity and mouse lethality of enterovirus 71 by virus binding and RNA accumulation enhancement. IUMS (International Union of Microbiological Societies), The XVth International Congress of Virology. Sapporo, Japan. Sep. 11-16.
Tuan YC, Huang SW, Wang JR. 2011. Antiviral effect of nitric oxide on enterovirus 71 replication. IUMS (International Union of Microbiological Societies), The XVth International Congress of Virology. Sapporo, Japan. Sep. 11-16.
Yeh MT, Wang JR. 2011. A Single Nucleotide in Stem Loop II of 5´-Untranslated Region Contributes to Virulence of Enterovirus 71 in Mice. 2011 International Symposium on RNA Viruses (Virus-Host Interactions), Taoyuan, Nov. 11-12.
Wang JR, Huang SW, Yeh MT, Kung YH, Wang SM, Yu CK, Liu CC, Su IJ. 2011. Genetic analysis of enterovirus 71 and its impact on pathogenesis. 2011 International Symposium on Infectious Disease and Signal Transduction. Tainan. Nov. 19-20.
Kao LL, Wang JR. The effect of NS1 genetic variations of H3N2 influenza A virus on type I interferon response. 2011. 2011 International Symposium on Infectious Disease and Signal Transduction. Tainan. Nov. 19-20.
Yeh MT, Wang JR. A single nucleotide in stem loop II of 5´-untranslated region contributes to virulence of enterovirus 71 in mice. 2011 International Symposium on Infectious Disease and Signal Transduction. Tainan. Nov. 19-20.
Lin CH, Huang SW, Wang JR. Characterization of antigenic determinants of enterovirus 71 genotype B and C. 2011 International Symposium on Infectious Disease and Signal Transduction. Tainan. Nov. 19-20.
Wang JR. 2011. Genetic and antigenic analyses of enterovirus 71 and their implications. 2011 First Cross Strait Symposium on Development of Drug and Biomedical Products. 2011年第一屆兩岸醫藥品研發合作研討會. Taipei. Dec. 13-14.
Huang SW, Wang YF, Yu CK, Su IJ, Wang JR. 2011. VP2149M mutation enhances enterovirus 71 infectivity in vitro and mouse lethality in vivo by increasing RNA release and accumulation. The 20th annual meeting of Taiwan Society of Microbiology, Tainan, Taiwan, Dec. 18. Huang SW received T Oral Presentation Award.
Yeh MT, Wang JR. 2011. Comparative analysis of codon usage bias between virulent and avirulent enterovirus 71. The 20th annual meeting of Taiwan Society of Microbiology, Tainan, Taiwan, Dec. 18.
Wang JR, Lim CY. (2012) Analysis of receptor binding profile of swine-origin and human influenza A H1N1 virus. 2012 First International Conference on BioNano Innovation. Brisbane, Australia. July 18-20.
Wang JR.(2012) Returning of EV71: epidemiology and genetic analysis. International Minisymposium on Reemerging of Enterovirus 71-Southeast Asia and Taiwan Universities (SATU) Joint Research Scheme on EV71, Tainan, Taiwan, Sep. 13.
Lin YT, Tsai HP, Kuo PH, Lin CW, Wang JR.(2012) Analysis of coxsackievirus A9 isolated from 2007 to 2011. The 2012 annual meeting of the Chinese Society of Medical Technology, Taipei, Taiwan, Nov. 4.
Wang JR.(2012) Impact of genetic variations of enterovirus 71 on antigenicity and virulence. 2012 International Symposium on RNA Viruses (Virus-Host Interactions), Taoyuan, Taiwan, Nov. 9-10.
Wang SL, Wang SM, Liu CC, Wang JR.(2012) Molecular epidemiology of respiratory adenovirus in Taiwan from 2002 to 2011. 2012 International Symposium on Infectious Disease and Signal Transduction. Tainan. Nov. 11.
Cheng HL, Huang SW, Wang JR.(2012) Characterization of EV71 virulence determinants. The 21th annual meeting of Taiwan Society of Microbiology, Tainan, Taiwan, Dec. 16.
Chang YT, Wang JR.(2012) Analysis of neuraminidase of 2009 pandemic and seasonal influenza H1N1 viruses. The 21th annual meeting of Taiwan Society of Microbiology, Tainan, Taiwan, Dec. 16.
Cai YY, Tsai HP, Kuo PH, Lin IT, Ko CY, Yan JJ, Wang JR.(2013) Respiratory syncytial virus infections among young children from 2009 to 2013 in southern Taiwan. The 22th annual meeting of Taiwan Society of Microbiology, Taipei, Taiwan, Dec. 15.
Hung SJ, Wang JR.(2013) Effect of genetic variations of influenza virus nucleoprotein on viral RNA transcription and replication. The 22th annual meeting of Taiwan Society of Microbiology, Taipei, Taiwan, Dec. 15.
Hsu WY, Wang JR.(2013) Analysis of the effect of genetic variations on viral properties of enterovirus 71 from 2008 and 2012 The 22th annual meeting of Taiwan Society of Microbiology, Taipei, Taiwan, Dec. 15.
Wang JR.(2013) Genetic, antigenic and serology analyses of human influenza viruses in southern Taiwan. International Conference on Influenza Research. Tokyo Metropolitan Institute of Medical Science, Feb 15.
Wang JR.(2013) Impact of enterovirus 71 evolution on antigenicity and virulence. Symposium on Enterovirus 71. Chulalongkorn University, Thailand. Feb. 28.
Wang JR.(2013) Impact of genetic variations of enterovirus 71 on antigenicity and virulence. ASEAN HFMD Scientific Workshop 2013 in Biopolis, Singapore, April 11-12.
Wang JR.(2013) EV71 vaccine development in NHRI Taiwan. ASEAN HFMD Scientific Workshop 2013 in Biopolis, Singapore, April 11-12.
Hung SJ, Huang SW, Tsai HP, Kuo PH, Wang JR.(2013). Epidemiology and genetic analysis of 2009 pandemic H1N1 influenza viruses from 2009 to 2012 in Taiwan. The 29th Clinical Virology Symposium, Daytona Beach, Florida, April 26- May 1.
Wang JR.(2013) Highlights on 2013 Clinical Virology Symposium. 2013 Clinical Virology Symposium on Diagnosis and Research. Chang Gung University Hospital. June 15.
Wang JR.(2013) Impact of enterovirus 71 evolution on antigenicity and virulence. Symposium on New Development in Clinical Microbiology and Virology. Department of Health, Tainan City Government. June 18.
Wang JR.(2013) Avian influenza and influenza A (H7N9) virus. Symposium on New Development in Clinical Microbiology and Virology. Department of Health, Tainan City Government. June 18.
Tai CH, Lin CH, Huang SW, Wang JR.(2013) VP1 98 Contributes to antigenic variations between genotype B4 and B5 of enterovirus 71. The 32nd annual meeting of the American Society for Virology, The Pennsylvania State University, July 20-24.
Wang YF, Huang SW, Linsuwanon P, Chan YF, Poovorawan Y, Wang JR.(2013) Antigenic variations among enterovirus 71 genotypes by using human antisera from different countries. The 32nd annual meeting of the American Society for Virology, The Pennsylvania State University, July 20-24.
Wang JR, Chang CL, Tai CH, Kuo PH, Tsai HP. (2013) Molecular epidemiology of enterovirus 71 from 1998 to 2012 in Taiwan. The 32nd annual meeting of the American Society for Virology, The Pennsylvania State University, July 20-24.
Wang SL, Kuo PH, Tsai HP, Wang JR.(2013) High incident adenoviral co-infections along with repeated infections revealed via a decade of molecular epidemiology study. The 32nd annual meeting of the American Society for Virology, The Pennsylvania State University, July 20-24.
Tsai HP, Lin IT, Kuo PH, Ko CY, Tsai YY, Yan JJ, Wang JR.(2013) Evaluation of commercial realtime PCR assays for quantification of Epstein-Barr virus DNA in plasma. Nov. 2.
Tsai HP, Kuo PH, Tsai YY, Lin IT, Ko CY, Tsai HN, Chen JC, Yan JJ, Wang JR.(2014) Comparison of Two Automated and Standardized CMV Viral Load Assays. Cross-Strait Laboratory Medicine Symposium in 2014. Tainan, Taiwan, Aug. 23-24.
Wang JR.(2014) Genetic evolution of enterovirus 71 and its impact on virulence and antigenicity. The Tenth Across the Taiwan Strait Symposium on Cell Biology, Penghu, April 21-25.
Chang CL, Huang SW, Wang JR.(2014) Phylogenetic evolution and whole-genome analysis identified two subgenotypes of coxsackievirus A16 circulating in Taiwan from 1998 to 2013. The 33rd annual meeting of the American Society for Virology, The Colorado State University, June 21-25.
Huang SW, Huang IH, Wang JR.(2014) Viral quasispecies plays a role in disease severity of enterovirus 71. The 33rd annual meeting of the American Society for Virology, The Colorado State University, June 21-25
Hung SJ, Tsai KC, Huang SW, Wang JR.(2014) Epidemiology and genetic analysis of 2009 pandemic Influenza A/ H1N1 viruses from 2009 to 2013 in Taiwan. IUMS (International Union of Microbiological Societies), The XVIth International Congress of Virology. Montreal, Canada. July 27-Aug. 1.
Tsai HP, Kuo PH, Tsai YY, Lin IT, Ko CY, Tsai HN, Chen JC, Yan JJ, Wang JR. (2014) Comparison of Two Automated and Standardized CMV Viral Load Assays. Cross-Strait Laboratory Medicine Symposium in 2014. Tainan, Taiwan, Aug. 23-24.
Wang JR. (2014) Lessons from enterovirus 71 epidemics: evolution of reemerging viruses and its impact. 2014 International Symposium on Infectious Disease and Signal Transduction. Tainan, Taiwan. Nov. 1-2.
Cheng CK, Huang SW, Wang JR. (2014) Development of a recombinant virus for enterovirus 71 vaccine candidate. 2014 International Symposium on Infectious Disease and Signal Transduction. Tainan. Taiwan. Nov. 1-2.
Tai CH, Wang JR. (2014) Crossing species barrier of novel influenza virus from viral evolution. Mini-symposium on Influenza and Emerging Pathogens. Dec. 6.
Cheng CK, Huang SW, Wang JR. (2014) Development of a recombinant virus for enterovirus 71 vaccine candidate. The 23th annual meeting of Taiwan Society of Microbiology, Taipei, Taiwan. Dec. 14.
Ko CY, Tsai HP, Kuo PH, Lin IT, Tsai YY, Tsai HN, Chang KC, Wang JR. (2014) Evaluation of molecular assays to detect toxigenic Clostridium difficile toxin in stool. The 23th annual meeting of Taiwan Society of Microbiology, Taipei, Taiwan. Dec. 14.
Lin IT, Tsai HP, Kuo PH, Tsai YY, Tsai HN, Ko CY, Chang KC, Wang JR. (2014) Comparison of three commercial rapid diagnostic kits for detection of influenza A/B virus. The 23th annual meeting of Taiwan Society of Microbiology, Taipei, Taiwan. Dec. 14.
Tsai YY, Tsai HN, Tsai HP, Kuo PH, Lin IT, Ko CY, Chang KC, Wang JR. (2015) Risk assessment of toxigenic Clostridium difficile nucleic acid testing by Failure Mode and Effects Analysis. The 7th Asia-Pacific Forum of Medical Laboratory Science. Tainan, Taiwan. April 11-12.
Tai CH, Tsai HP, Kuo PH, Wang JR. (2015) Continuing Changes of Human Influenza Viruses. 台灣醫學會104年春季學術演講會. Tainan, Taiwan. May 23-24.
Huang SW, Wang JR. (2015) Dynamics of enterovirus 71 evolution: from global to the host. The 15th SCBA (Society of Chinese Bioscientists in America) International Symposium. Taipei, Taiwan. June 26-29.
Huang SW, Wang JR. (2015) Dynamics of enterovirus 71 evolution: from global to the host. International Symposium on Dengue virus, Enterovirus 71 and Tumor- Associated Viruses. Tainan, Taiwan. June 30.
Hsu WY, Huang SW, Cheng HL, Tsai HP, Wang JR. (2015) Re-emergent enterovirus 71 genotype B5 in 2012 belongs to a new sub-lineage of B5 with predominate substitutions in 3D polymerase and higher replication rate. The 115th general meeting of the Australia Society for Microbiology. Canberra, Australia. July 12-15.
Huang SW, Wang JR. 2015. Impact of enterovirus 71 evolution on virulence and antigenicity. 10th Asia-Pacific Congress of Medical Virology 2015 (APCMV 2015). Taipei, Taiwan, Oct. 15-18.
Huang SW, Huang YH, Wang JR. 2015. Haplotype preference of enterovirus 71 in human central nervous system. 10th Asia-Pacific Congress of Medical Virology 2015 (APCMV 2015). Taipei, Taiwan, Oct. 15-18.
Hsu YM, Hung SJ, Wang JR. 2015. The effect of K31R and S450G substitutions of influenza A nucleoprotein on viral replication. The 21st annual meeting of Taiwan Society of Microbiology, Taipei, Taiwan, Oct. 17..
Huang YH, Huang SW, Wang JR. 2015. Identify VP1-31G in enterovirus A71 fatal infection by deep-sequencing. The 23th annual meeting of Taiwan Society of Microbiology, Taipei, Taiwan, Oct. 17.
Kuo PH, Tsai HP, Tsai YY, Lin IT, Ko CY, Tsai HN, Wang JR. 2015. Evaluation of three multiple real-time PCR assays for the detection of herpes simplex virus type 1/2 and varicella-zoster virus. The 2015 annual meeting of the Taiwan Society of Laboratory Medicine, Taipei, Nov. 8.
Tsai HP, Tsai YY, Kuo PH, Lin IT, Ko CY, Tsai HN, Chen JC, Chang KC, Chen TY, Wang JR. 2016. Establish standardized cytomegalovirus viral load assays for monitoring treatment outcome in bone marrow or hematopoietic stem cell transplant recipients. 2016 Asia-Pacific City Forum of Biomedical Laboratory Science. Taichung, Taiwan. April 16-17.
Lin IT, Tsai HP, Kuo PH, Tsai YY, Ko CY, Tsai HN, Chang KC, Wang JR. 2016. Molecular epidemiology analysis of Echovirus in a cluster outbreak of aseptic meningitis. 2016 Asia-Pacific City Forum of Biomedical Laboratory Science. Taichung, Taiwan. April 16-17.
Wang JR. 2016. Good microbiological laboratory practice and techniques. 2016生物安全官教育訓練研習會. 社團法人台灣環境測試驗證協會Kaohsiung Medical University, May 13.
Huang SW, Huang YH, Wang JR. 2016. Detection of viral quasispecies in enterovirus A71 clinical isolates by next-generation sequencing. The 32nd Clinical Virology Symposium, Daytona Beach, Florida, May 18- 22.
Huang SW, Wang JR. 2016. Genome plasticity of enterovirus A71 affects antigenicity, viral fitness and pathogenicity. Hand, Foot and Mouth Disease International Conference, July 25-26, Biopolis, Singapore.
Huang SW, Cheng CK, Wang JR. 2016. Development of a Synthetic Virus for Enterovirus A71 Vaccine Candidate. International Congress of Immunology, Aug 21-26, Melbourne, Australia.

Other publications (in Chinese)

Hsiung GD, Wang JR. 1995. NCKUH Virology Laboratory - establishment, current status, and future. J. National Cheng Kung University 174: 14-15.
Wang JR. 1995. Laboratory diagnosis of viral infections. J. National Cheng Kung University Medical college 1: 126-128.
Wang JR, Kuo PH. 1995. Laboratory manual for viral diagnosis. (34 pages manual).
Hsiung GD, Wang JR. 1995. Laboratory test for viral diagnosis. Pathology Newsletter National Cheng Kung University Hospital (NCKUH) 1 (1):3-4 .
Wang JR, Kuo PH. 1995. Viral watch report. Pathology Newsletter NCKUH 1 (4):4.
Wang JR, Kuo PH. 1995. Viral watch report. Pathology Newsletter NCKUH 1 (7):4.
Wang JR. 1996. National Cheng Kung University Hospital Virology Laboratory - one year progress. Pathology Newsletter NCKUH 1 (10):1-2.
Kuo PH, Wang JR. 1996. Common respiratory viral infections. Pathology Newsletter NCKUH 2 (2):1-2.
Liu YC, Chang LR, Kuo PH, Wang JR. 1996. Prion. Pathology Newsletter NCKUH 2 (2):2-3.
Kuo PH, Wang JR. 1996. Viral watch report. Pathology Newsletter NCKUH 2(2):4.
Kuo PH, Wang JR. 1996. A new viral test - ELVIS. Pathology Newsletter NCKUH 2 (7):2-4.
Kuo PH, Liu CZ, Yee JJ, Wang JR. 1997. Viral watch report. Pathology Newsletter NCKUH 2 (10):3-4.
Wang JR. 1997. National Cheng Kung University Hospital Virology Laboratory - two years progress. Pathology Newsletter NCKUH 2(10):2-3.
Kuo PH, Tsai HP, Wang JR. 1998. Viral watch report, 1997. Pathology Newsletter NCKUH 3 (10):1-3.
Kuo PH, Wang JR. 1998. National Cheng Kung University Hospital Virology Laboratory - three years progress. Pathology Newsletter NCKUH 4(1):1-3.
Tsai HP, Wang JR. 1998. Laboratory diagnosis of CNS viral infections. Pathology Newsletter NCKUH 4 (1):4-8.
Kuo PH, Tsai HP, Wang JR. 1998. Viral watch report. Pathology Newsletter NCKUH 4 (7):1-4.
Wang YF, Wang JR. 1999. Virus watch report. 1999 Jan-March. Pathology Newsletter NCKUH 4(11):1-2.
Wang YF, Wang JR. 1999. Viral watch report, 1998. Pathology Newsletter NCKUH 4 (11):2-4.
Chen PF, Wang JR. 1999. Nipah virus outbreak-Malaysia. Pathology Newsletter NCKUH 4(12):1-2.
Huang CS, Tsai HP, Wang JR. 1999. Virus watch report: What do we have this summer? 1999 April-Aug. Pathology Newsletter NCKUH 5(4):1-4.
Liao PR, Tsai HP, Wang JR. 2000. Virus watch report: concurrent epidemic of influenza and adenovirus, 1999 Sep.-Dec. Pathology Newsletter NCKUH 5(7):1-4.
Wang YF, Wang JR. 2000. Outbreak of West Nile virus encephalitis in New York. Pathology Newsletter NCKUH 5(10): 1-3.
Tsai HP, Wang JR. 2001. What enteroviruses do we have this summer? Virus watch report: 2001 Jan-May. Pathology Newsletter NCKUH 5(12):1-4.
Tsai HP, Wang JR. 2002. Influenza activity in southern Taiwan in 2001. Prevention and control of influenza virus. Pathology Newsletter NCKUH 6(6):1-4.
Huang SW, Wang JR. 2005. Avian influenza. Science Development 396:76-81.
林智暉、王貞仁. 流感病毒的實驗診斷.【認識H5N1新型流感】國衛院台灣流感研究小組第一版2005年11月.
林智暉、王貞仁. 流感病毒的實驗診斷.【認識H5N1新型流感】國衛院台灣流感研究小組第二版2006年4月.
林智暉、王萱蓁、王貞仁. 流感病毒的實驗診斷.【認識H5N1流感】國衛院台灣流感研究小組第三版2008年3月.
林智暉、王萱蓁、王貞仁. 流感病毒的實驗診斷.【認識H5N1新型流感】國衛院台灣流感研究小組第四版2009年5月.
Kuo PH, Wang JR. 2015. MERS新興的中東呼吸症候群冠狀病毒. Science Development 505: 54-59