Education

• The Institute of Basic Medical Science, National Cheng Kung University, Tainan, Taiwan
• Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, Taiwan

Publication

• Chen PS+,Wang KC+(equal contribution); Chao TH; Chung HC; Tseng SY; Luo CY; Shi GY; Wu HL; Li YH*. Recombinant Thrombomodulin Exerts Anti-autophagic Action in Endothelial Cells and Provides Anti-atherosclerosis Effect in Apolipoprotein E Deficient Mice. Scientific Reports. 2017;7: 3284.
• Lai CH, Wang KC, Kuo CH, Lee FT, Cheng, TL, Chang, BI, Yang YJ, Shi GY,Wu HL*. Recombinant Adeno-Associated Virus Vector Carrying the Thrombomodulin Lectin-like Domain for the Treatment of Abdominal Aortic Aneurysm. Atherosclerosis. 2017;262:62-70.
• Hsu YY, Shi GY, Wang KC, Ma CY, Cheng TL, Wu HL*. Thrombomodulin promotes focal adhesion kinase activation and contributes to angiogenesis by binding to fibronectin.Oncotarget. 2016;7:68122-68139.
• 4Tai HC, Tsai PJ, Chen JY, Lai CH, Wang KC, Teng SH, Lin SC, Chang AY, Jiang MJ, Li YH, Wu HL, Maeda N, Tsai YS*.Peroxisome Proliferator–Activated Receptor γ Level Contributes to Structural Integrity and Component Production of Elastic Fibers in the Aorta. Hypertension. 2016;67:1298-1308.
• Lai CH, Wang KC,Lee FT, Tsai HW, Ma CY, Cheng TL, Chang BI, Yang YJ, Shi GY*, Wu HL*. Toll-like Receptor 4 is Essential in the Development of Abdominal Aortic Aneurysm. PLoS One. 2016;11:e0146565.
• Wang KC, Li YH, Shi GY, Tsai HW, Luo CY, Cheng MH, Ma CY, Hsu YY, Cheng TL, Chang BI, Lai CH*, Wu HL*. Membrane-bound thrombomodulin regulates macrophage inflammation in abdominal aortic aneurysm. ArteriosclerThrombVasc Biol.2015;35:2412-22.
• Cheng TL, Lai CH, Chen PK, Cho CF, Hsu YY, Wang KC, Lin WL, Chang BI, Liu SK, Wu YT, Hsu CK, Shi GY, Wu HL*. Thrombomodulin promotes diabetic wound healing by regulating toll-like receptor 4 expression. J Invest Dermatol. 2015;135:1668-1675.
• Cheng TL, Wu YT, Lai CH, Kao YC, Kuo CH, Liu SL, Hsu YY, Chen PK, Cho CF, Wang KC, Lin WL, Chang BI, Chen CM, Weiler H, Shi GY*, Wu HL*. Thrombomodulin regulates keratinocyte differentiation and promotes wound healing. J Invest Dermatol. 2013;133:1638-1645.
• Kao YC, Jiang SJ, Pan WA, Wang KC, Chen PK, Wei HJ, Chen WS, Chang BI, Shi GY*, Wu HL*. The epidermal growth factor-like domain of CD93 is a potent angiogenic factor. PLoS One. 2012;7:e51647.
• Chang PC, Wu HL, Lin HC, Wang KC, Shi GY*. Human plasminogen kringle 1-5 reduces atherosclerosis and neointima formation in mice by suppressing the inflammatory signaling pathway. J ThrombHaemost. 2010;8:194-201.
• Kao TT, Wang KC, Chang WN, Lin CY, Chen BH, Wu HL, Shi GY, Tsai JN, Fu TF*. Characterization and comparative studies of zebrafish and human recombinant dihydrofolatereductases--inhibition by folic acid and polyphenols. Drug MetabDispos. 2008;36:508-516.